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Cell Motility and Cytoskeletal Regulation in Invasion and Metastasis

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Journal of Mammary Gland Biology and Neoplasia Aims and scope Submit manuscript

Abstract

Cell motility and chemotaxis can make important contributions to the metastatic cascade. Cell migration pathways in general play significant roles in a variety of physiological processes that can be “hijacked” by cancer cells. Both growth factors and chemokines provide important chemotactic signals in development and metastasis. Receptor activation, following binding of a growth factor or a chemokine, leads to dynamic morphological changes in the actin cytoskeleton network via a variety of distinct and interconnected pathways, resulting in translocation of the cell up a chemoattractant gradient. Such gradients may be produced by stromal cells in the local microenvironment, including macrophages and fibroblasts. A better understanding of the mechanisms of cell motility and cytoskeletal regulation may provide novel therapeutic strategies that would block metastatic progression, reducing dissemination of tumor cells and increasing patient survival.

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Abbreviations

ARP2/3:

actin-related protein-2/3

CAF:

cancer associated fibroblast

CXCR4:

CXC motif chemokine receptor 4

ECM:

extracellular matrix

EGFR:

epidermal growth factor receptor

EMT:

epithelial–mesenchymal transition

FGF:

fibroblast growth factor

GPCR:

G-protein Coupled Receptor

HRG:

heregulin

HGF:

hepatocyte growth factor

MLC2:

myosin II light chain

MRCK:

myotonic dystrophy kinase-related Cdc42-binding kinase

PI3K:

phosphoinositide 3-kinase

PLC:

phospholipase C

SDF-1:

stromal derived factor 1

ROCK:

rho signals through rho-kinase

RTK:

receptor tyrosine kinase

TAM:

tumor associated macrophages

WASP:

Wiskott–Aldrich syndrome protein

WAVE:

WASP-family verprolin-homologous proteins

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Acknowledgements

Dmitriy Kedrin is supported by DOD pre-doctoral traineeship award # BC061403. Jacco van Rheenen is supported by a fellowship from the Dutch Cancer Society. John Condeelis, Lorena Hernandez and Jeffrey Segall are supported by CA100324. We would like to apologize to the authors whose work could not be included in this review due to space limitations. J. van Rheenen and L. Hernandez contributed equally to the review.

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Authors and Affiliations

  1. Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, USA

    Dmitriy Kedrin, Jacco van Rheenen, Lorena Hernandez, John Condeelis & Jeffrey E. Segall

  2. Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, NY, USA

    John Condeelis

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  1. Dmitriy Kedrin
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  2. Jacco van Rheenen
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Correspondence to Jeffrey E. Segall.

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Kedrin, D., van Rheenen, J., Hernandez, L. et al. Cell Motility and Cytoskeletal Regulation in Invasion and Metastasis. J Mammary Gland Biol Neoplasia 12, 143–152 (2007). https://doi.org/10.1007/s10911-007-9046-4

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