Journal of Mathematical Chemistry

, Volume 53, Issue 1, pp 29–40 | Cite as

Quantitative study of BSA coating silica nanoparticle

Original Paper

Abstract

The loading of biomolecules on nanoparticles might be thought of as a first step to design a cargo in drug delivery system. Here, we study a quantity of bovine serum albumin (BSA) surrounding the silica nanoparticle. The silica nanoparticle is modeled as a perfect sphere whereas the BSA is represented by an ellipsoid. On utilizing a continuous approximation, the electrostatic and van der Waals interactions can be analytically expressed. Further, a number of BSA molecules coating on the nanoparticles of various sizes can be simply determined as a function of the protein ring radius. Our finding is in a good agreement found in experiment and this can be a guide to evaluate the number of protein on other type of spherical nanoparticles.

Keywords

Bovine serum albumin Silica nanoparticle Lennard-Jones function Coulombic function 

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  1. 1.Department of Mathematics, Faculty of ScienceMahidol UniversityBangkokThailand
  2. 2.Center for BioinformaticsSaarland UniversitySaarbrückenGermany

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