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Synthesis of Graphene Oxide/Iron Oxide/Au Nanocomposite for Quercetin Delivery

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Abstract

This study focused on developing a superparamagnetic graphene oxide-based nanocomposite consisting of iron oxide (IO) and gold nanoparticles for quercetin delivery. For this purpose, the structure and morphology of the designed nanocomposite (GO/IO/Au) were investigated by several characterization methods such as fourier-transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) analysis, vibrating-sample magnetometer (VSM) analysis, field emission scanning electron microscopy (FESEM) and Transmission electron microscopy (TEM). Then, the biocompatibility of the synthesized nanocomposite was studied by Brine shrimp Artemia lethality assay, red blood cell hemolysis assay, and MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. Moreover, the GO/IO/Au nanocomposite efficiency as an anticancer drug delivery system was evaluated in vitro conditions. The results showed that the designed nanocomposite is highly biocompatible and possesses a favorable magnetization (Ms = 29.2 emu.g−1) making it a good candidate for biomedical applications. Also, it was confirmed that GO/IO/Au nanocomposite is a potent drug carrier that can effectively deliver quercetin to cancer cells.

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Acknowledgements

This work was supported by the Zanjan University of Medical Sciences.

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Authors and Affiliations

  1. Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Postal Code 45139-56184, Zanjan, Iran

    Azita Sharifi Saqezi, Mehraneh Kermanian & Somayeh Sadighian

  2. Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

    Mehraneh Kermanian, Ali Ramazani & Somayeh Sadighian

  3. Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

    Mehraneh Kermanian & Somayeh Sadighian

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  1. Azita Sharifi Saqezi
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The electronic supporting information includes the XRD pattern of the pristine GOsheet and images of the hemolysis assay.

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Saqezi, A.S., Kermanian, M., Ramazani, A. et al. Synthesis of Graphene Oxide/Iron Oxide/Au Nanocomposite for Quercetin Delivery. J Inorg Organomet Polym 32, 1541–1550 (2022). https://doi.org/10.1007/s10904-022-02259-3

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