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Plasmonic Superparamagnetic SPION@Ag@chitosan Core-shell: Uptake and Nitric Oxide Inhibition by Colorectal Cell Lines

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Abstract

Using Fusarium oxysporum species (F. oxysporum), a green synthesis of super-paramagnet iron oxide @silver@ Chitosan (SPION@Ag@Cs) was achieved. The physico-chemical characteristics of the SPION@Ag@Cs nanocomposite revealed the development of superparamagnetic phases of iron oxide (Fe2O3), as well as fluorescence, Raman absorption, and biocompatibility. Drug and gene delivery, and diagnosis, are all possibilities for the nanocomposite. The uptake of nitric oxide by HT-29 colorectal cell lines is examined in this article, for up to 72 h, the cytotoxicity of the HCT116 cell line was investigated. These characteristics were compared to Streptomyces griseus fungal species (S. griseus) which develops Fe3O4 under the same preparation conditions.

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Acknowledgements

Prof. Dr. Wafaa Hagag’s generous contribution of S.griesus is greatly appreciated.

Funding

The National Research Center in Egypt generously funded the work in this paper through internal project number 12010129.

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Authors and Affiliations

  1. Physics Division, Spectroscopy Department, National Research Centre, Dokki, 12622, Giza, Egypt

    M. M. Eid & A. M. Ismail

  2. Chemistry of Natural and Microbial Products, Pharmaceutical Industry Research Division, National Research Centre, Dokki, 12622, Giza, Egypt

    Zeinab A. Elshahid

  3. Agricultural and Biological Division, Agricultural Microbiology Department, National Research Centre, Dokki, 12622, Giza, Egypt

    Fatma H. Abd Elzaher

  4. Pharmaceutical Sciences Division, Department of Pharmacognosy, National Research Centre, Dokki, 12622, Giza, Egypt

    K. Mahmoud & M. El-Manawaty

Authors
  1. M. M. Eid
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  2. A. M. Ismail
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  3. Zeinab A. Elshahid
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  4. Fatma H. Abd Elzaher
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  5. K. Mahmoud
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  6. M. El-Manawaty
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Correspondence to A. M. Ismail.

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Eid, M.M., Ismail, A.M., Elshahid, Z.A. et al. Plasmonic Superparamagnetic SPION@Ag@chitosan Core-shell: Uptake and Nitric Oxide Inhibition by Colorectal Cell Lines. J Inorg Organomet Polym 32, 931–940 (2022). https://doi.org/10.1007/s10904-021-02213-9

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  • DOI: https://doi.org/10.1007/s10904-021-02213-9

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