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A New 3D La(III) Complex: Gas Adsorption Properties and Inhibitory Activity on the Glioma by Regulating the Expression of VEGF Signaling Pathway

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Abstract

This article introduces a La(III) compound with the formula of [La2(tdc)3(DMA)2(H2O)]n (1, H2tdc = 2,5-thiophenedicarboxylic acid, DMA = N,N′-dimethylacetamide), whose feature can be analyzed by single crystal X-ray diffraction analysis, thermal analysis, elemental analysis and powder X-ray diffraction analysis. It is easy to remove the coordinated solvent molecules of 1 through thermal activation, affording the solvent-free sample (1a) with large one-dimensional opened channels. Gas adsorption investigations have shown that 1a shows high CO2 sorption ability of 79.2 m3/g under the condition of 298 K and 1 atmosphere, and the moderate adsorption selectivity of CH4 for CO2. This study evaluates the application value of La(III) on the glioma treatment and in the meanwhile explores the related mechanism. The Cell Counting Kit-8 assay was performed to measure of U-373MG glioma cancer cells after compound treatment. The activation of VEGF signaling pathway in the glioma cancer cells was determined by performing the real time RT-PCR.

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Data Availability

The table showing the bond lengths and angles for complex 1 (Table S1), the figure showing the coordination mode of tdc2− ligand (Fig. S1) and the PXRD profiles of 1 (Fig. S2), the information could be found in the supporting information file.

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Authors and Affiliations

  1. The First Department of Neurosurgery, The Third Affiliated Hospital of Qiqihar Medical College, Qiqihar, Heilongjiang, China

    Yan-Guo Zhang, Ming-Fu Zhang, Qiang Wang, Jiu-Jiang Zhang & Xiang-Rui Chen

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  1. Yan-Guo Zhang
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  2. Ming-Fu Zhang
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  3. Qiang Wang
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Zhang, YG., Zhang, MF., Wang, Q. et al. A New 3D La(III) Complex: Gas Adsorption Properties and Inhibitory Activity on the Glioma by Regulating the Expression of VEGF Signaling Pathway. J Inorg Organomet Polym 31, 4188–4194 (2021). https://doi.org/10.1007/s10904-021-02021-1

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