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Incorporation of 5-Nitroisatin for Tailored Hydroxyapatite Nanorods and its Effect on Cervical Cancer Cells: A Nanoarchitectonics Approach

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Abstract

Hydroxyapatite (HAP) have been widely used as bone implants for its biocompatibility, and bioactivity. Other approaches like scaffold development, drug delivery and nanomaterials preparation are explored recently. Herein, hydroxyapatite incorporated with 5-nitroisatin (HAP-5 N) were prepared and tested for its anticancer potential. The prepared HAP-5 N were found to have rod like structures as seen using scanning electron microscopic analysis. The structural elucidation of 5-nitroisatin were confirmed by performing 2D heteronuclear single quantum correlation experiment. The synthesized HAP-5 N were assessed for its possible role as an anticancer agent against cervical cancer (SiHa) cells. From the study, it was found that HAP-5 N is efficient in inhibiting the growth of cervical cancer cell lines.

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Acknowledgements

The authors would like to thank the management of Sathyabama Institute of Science and Technology, Chennai for its stanch support in research activities. Instrumentation facilities by Centre for Nanoscience and Nanotechnology (CNSNT), Sathyabama Institute of Science and Technology, Chennai is greatly acknowledged. V.K. would like to thank the Japan Society for the Promotion of Science (JSPS), Japan and Department of Science and Technology (DST) and Indian National Science Academy (INSA), India for his research fellowship.

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Authors and Affiliations

  1. Centre for Ocean Research (DST-FIST Sponsored Centre), MoES-Earth Science & Technology Cell (ESTC), Sathyabama Institute of Science and Technology, Jeppiaar Nagar, Rajiv Gandhi Salai, Chennai, 600119, India

    V. Karthick, C. M. Vineeth Kumar, V. Ganesh Kumar, T. Stalin Dhas, M. Ravi & J. Baalamurugan

  2. Centre of Biomedical Research (CBMR), Sanjay Gandhi Post-Graduate Institute of Medical Sciences Campus, Raibareli Road, Lucknow, 226014, India

    Dinesh Kumar

  3. International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki, 305-0044, Japan

    Katsuhiko Ariga

  4. Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, 277-8561, Japan

    Katsuhiko Ariga

  5. Interdisciplinary School of Indian System of Medicine, SRM Institute of Science and Technology, Kattankulathur, 603203, India

    K. Vasanth

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  1. V. Karthick
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Karthick, V., Kumar, D., Ariga, K. et al. Incorporation of 5-Nitroisatin for Tailored Hydroxyapatite Nanorods and its Effect on Cervical Cancer Cells: A Nanoarchitectonics Approach. J Inorg Organomet Polym 31, 1946–1953 (2021). https://doi.org/10.1007/s10904-021-01891-9

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