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A Fluorescent Sensor for Daunorubicin Determination Using 808 nm-excited Upconversion Nanoparticles

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Abstract

Daunorubicin is a common antineoplastic agent used for the treatment of lymphoma and acute leukemia. Here, we report an 808 nm-excited, citric acid coated, core–shell upconversion fluorescent sensor for daunorubicin (DAU) detection in aqueous solutions. The designed Nd3+ doped core–shell structure significantly raises the upconversion fluorescence intensity, while the presence of citric acid ligands helps to reduce the surface quenching effect exerted by water and improve the dispersibility. The upconversion fluorescence of nanoparticles is efficiently quenched in the presence of DAU via a fluorescence resonance energy transfer mechanism. The dynamic quenching constant was 1.58 × 104 M−1. The fluorescence intensity ratio showed a good linear response to DAU concentration in the range of 0.1 μM to 70 μM with a detection limit of 0.06 μM. The sensing method was simple, rapid, and low-cost and was further applied to determine the levels of DAU in urine with spike recoveries from 97.3% to 101.5%. The proposed fluorescent sensor holds great potential for in vivo imaging and detection of DAU.

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Acknowledgements

This research was funded by the National Natural Science Foundation of China (Grant No. 51805082), Natural Science Foundation of Jiangsu Province (Grant No. BK20170683) and Fundamental Research Funds for the Central Universities (Grant No. 2242020K40190).

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Authors and Affiliations

  1. School of Public Health, Southeast University, Nanjing, 210009, P.R. China

    Jiaying Zeng, Xiaoying Wang, Rongli Sun, Tianshu Wu, Qian Xu & Hui Jin

  2. Jiangsu Key Laboratory for Design & Manufacture of Micro/Nano Biomedical Instruments and School of Mechanical Engineering, Southeast University, Nanjing, 210096, P.R. China

    Yuan Jia & Jingwen Mo

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  1. Jiaying Zeng
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Zeng, J., Wang, X., Jia, Y. et al. A Fluorescent Sensor for Daunorubicin Determination Using 808 nm-excited Upconversion Nanoparticles. J Inorg Organomet Polym 31, 2868–2876 (2021). https://doi.org/10.1007/s10904-020-01872-4

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