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A Microporous Zn(II)–MOF for Solvent-Free Cyanosilylation and Treatment Effect Against Bacterial Infection on Burn Patients Via Inhibiting the Staphylococcus aureus Biofilm Formation

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Abstract

A novel metal–organic framework (MOF) based on Zn(II) ion as metal node was synthesized from tetrazole (HAT) and 1-benzimidazole-5-carboxylic acid (H2Bmic) as well as Zn(NO3)2·6H2O in DMF-water mixed solvent, and its chemical formula is [Zn2(Bmic)2(HAT)2](DMF)3 (1, DMF = N,N-dimethylformamide). The results show that the obtained activated 1a has catalytic activity for aromatic aldehydes cyanation under the existence of the trimethylsilyl cyanide (TMSCN), thus providing trimethylsilyl cyanohydrin in the form of shape along with size selection. In addition, a feasible synergistic mechanism of 1a for cyanosilylation of aldehyde also has been put forward. Furthermore, the treatment effect of the compound against Staphylococcus aureus on burn patients has been evaluated. Firstly, the inhibitory effect of the compound on the Staphylococcus aureus biofilm formation was evaluated in vitro via crystal violet staining experiment. Then, the treatment activity of the compound in vivo was detected by counting the colony-forming units (CFU) numbers in the local tissue of skin infection.

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References

  1. C. Zhou, H. Cai, A. Baruch, N. Lewin-Koh, M. Yang, F. Guo, D. Xu, R. Deng, W. Hazenbos, A.V. Kamath, PLoS ONE 14, e0224096 (2019)

    Article  CAS  Google Scholar 

  2. E. Ahmadi, M. Khojasteh, S.M. Mortazavi, F. Khan-Mohammadi, A. Kazemnia, J. Beheshtipour, M. Raeeszadeh, B.M.C. Infect, Dis. 19, 899 (2019)

    Google Scholar 

  3. N. Bravo-Santano, P. Capilla-Lasheras, L.M. Mateos, Y. Calle, V. Behrends, M. Letek, Sci. Rep. 9, 15435 (2019)

    Article  Google Scholar 

  4. A. Mahfoozi, H. Shirzad-Aski, H. Kaboosi, E.A. Ghaemi, Iran. J. Vet. Res. 20, 209–212 (2019)

    CAS  PubMed  PubMed Central  Google Scholar 

  5. F.H. Jawdat, J. Lin, S.X. Dou, M.-S. Park, A. Nattestad, J.H. Kim, Bull. Chem. Soc. Jpn. 92, 2012–2018 (2019)

    Article  CAS  Google Scholar 

  6. D.M. Chen, X.J. Zhang, J. Solid State Chem. 278, 120906 (2019)

  7. Y.Q. Su, Y.H. Qu, L. Fu, G.H. Cui, Inorg. Chem. Commun. 118, 108013 (2020)

    Article  CAS  Google Scholar 

  8. M.M. Fu, Y.H. Qu, V.A. Blatov, Y.H. Li, G.H. Cui, J. Solid State Chem. 289, 121460 (2020)

    Article  CAS  Google Scholar 

  9. Y.S. Shi, Y.H. Li, G.H. Cui, G.Y. Dong, CrystEngComm 22, 905–914 (2020)

    Article  CAS  Google Scholar 

  10. J.X. Li, Z.X. Du, Q.Y. Pan, L.L. Zhang, D.L. Liu, Inorg. Chim. Acta 509, 119677 (2020)

    Article  CAS  Google Scholar 

  11. J.X. Li, Z.X. Du, L.L. Zhang, D.L. Liu, Q.Y. Pan, Inorg. Chim. Acta 512, 119890 (2020)

    Article  CAS  Google Scholar 

  12. H. Du, C. Ma, W. Ma, H. Wang, Process Appl. Ceram. 12, 303–312 (2018)

    Article  CAS  Google Scholar 

  13. J.X. Li, Z.X. Du, J. Clust. Sci. 31, 507–511 (2020)

    Article  CAS  Google Scholar 

  14. D. Yuan, M. Sun, M. Zhao, S. Tang, J. Qi, X. Zhang, K. Wang, B. Li, Int. J. Electrochem. Sci. 15, 8761–8770 (2020)

    Article  Google Scholar 

  15. F.Z. Jin, C.C. Zhao, H.C. Ma, G.J. Chen, Y.B. Dong, Inorg. Chem. 58, 9253–9259 (2019)

    Article  CAS  Google Scholar 

  16. J. Amaro-Gahete, D. Esquivel, J.R. Ruiz, C. Jiménez-Sanchidrián, F.J. Romero-Salguero, Appl. Catal. A Gen. 585, 117190 (2019)

    Article  CAS  Google Scholar 

  17. G. Tiago, K. Mahmudov, M. Guedes da Silva, A. Ribeiro, L. Branco, F. Zubkov, A. Pombeiro, Catalysts 9, 284 (2019)

    Article  Google Scholar 

  18. Y. Jiang, J. Xu, Z. Zhu, C. Jiang, L. Ma, H. Wang, L. Wang, Y. Fan, Inorg. Chim. Acta 510, 119735 (2020)

    Article  CAS  Google Scholar 

  19. J. Li, Y. Ren, C. Qi, H. Jiang, Chem. Commun. 53, 8223–8226 (2017)

    Article  CAS  Google Scholar 

  20. A.K. Bharati, Somnath, P. Lama, K.A. Siddiqui, Inorg. Chim. Acta 500, 119219 (2020)

    Article  CAS  Google Scholar 

  21. M.Y. Sun, D.M. Chen, Polyhedron 147, 80–85 (2018)

    Article  CAS  Google Scholar 

  22. D.M. Chen, X.J. Zhang, CrystEngComm 21, 4696–4700 (2019)

    Article  CAS  Google Scholar 

  23. Z. Ma, V.A. Aliyeva, D.B. Tagiev, F.I. Zubkov, F.I. Guseinov, K.T. Mahmudov, A.J.L. Pombeiro, J. Organomet. Chem. 912, 121171 (2020)

    Article  CAS  Google Scholar 

  24. Z. Zhang, J. Chen, Z. Bao, G. Chang, H. Xing, Q. Ren, RSC Adv. 5, 79355–79360 (2015)

    Article  CAS  Google Scholar 

  25. W. Jiang, J. Yang, Y.Y. Liu, S.Y. Song, J.F. Ma, Inorg. Chem. 56, 3036–3043 (2017)

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatological, Xianyang Hospital of Yan’an University, Xianyang, Shaanxi, China

    Xiao-Yan Chen

  2. Burn Center of PLA, Department of Burns and Cutaneous Surgery, Xijing Hospital, the Air Force Medical University, Xi’an, Shaanxi, China

    Peng Ji

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  1. Xiao-Yan Chen
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  2. Peng Ji
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Chen, XY., Ji, P. A Microporous Zn(II)–MOF for Solvent-Free Cyanosilylation and Treatment Effect Against Bacterial Infection on Burn Patients Via Inhibiting the Staphylococcus aureus Biofilm Formation. J Inorg Organomet Polym 31, 492–499 (2021). https://doi.org/10.1007/s10904-020-01759-4

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