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A Luminescent Eu(III) Coordination Polymer: Selective Detection of p-Nitroaniline and Treatment Effect on Colon Cancer by Inhibiting TRIB3 Mediated Cell Proliferation and Migration

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Abstract

By employment of the flexible bis-(imidazole-4,5-dicarboxylate) ligand (H4L) ligand, a new luminescent Eu(III)-containing coordination polymer {[Eu(HL)(H2O)2]·2(H2O)}n has been successfully synthesized under hydrothermal condition by reaction of Eu(NO3)3·6H2O with H4L with the presence of NaOH as the pH modulator. The chemical composing of the as-prepared complex 1 has been determined via the elemental analysis and the structural arrangement was probed via the single crystal X-ray diffraction. Furthermore, complex 1 could also be applied as a luminescent sensor for the detection of p-nitroaniline, which has high sensitivity and selectivity. In biological research, the related anti-colon cancer activity on SW480 cancer cells was further evaluated. Firstly, the effect of compound on TRIB3 gene expression was evaluated by RT-PCR. The CCK-8 and transwell assay were next be performed to detect the inhibitory function of compound on SW480 cancer cell proliferation and migration. Finally, the results obtained through molecular docking simulation shed light on the understanding of Eu(II) metallic complex on DNA.

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Author notes

  1. Tian-Qing Cui and Lei Shi have contributed equally to this work.

Authors and Affiliations

  1. Department of Gastroenterology, Inner Mongolia People’s Hospital, Hohhot, Inner Mongolia, China

    Tian-Qing Cui, Hui-Ming Zhang, Yu-Ting Yun & Niu Shi

  2. Clinical Nutrition Center, Inner Mongolia People’s Hospital, Hohhot, Inner Mongolia, China

    Lei Shi

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  1. Tian-Qing Cui
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  2. Lei Shi
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  3. Hui-Ming Zhang
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  4. Yu-Ting Yun
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Correspondence to Niu Shi.

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Cui, TQ., Shi, L., Zhang, HM. et al. A Luminescent Eu(III) Coordination Polymer: Selective Detection of p-Nitroaniline and Treatment Effect on Colon Cancer by Inhibiting TRIB3 Mediated Cell Proliferation and Migration. J Inorg Organomet Polym 30, 1752–1759 (2020). https://doi.org/10.1007/s10904-019-01324-8

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  • DOI: https://doi.org/10.1007/s10904-019-01324-8

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