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Zirconium Based Nano Metal–Organic Framework UiO-67-NH2 with High Drug Loading for Controlled Release of Camptothecin

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Abstract

A zirconium-based nano metal–organic framework (NMOF) UiO-67-NH2 was prepared solvothermally using shape modifier triethylamine. Its loading capacity for topoisomerase inhibitor compound camptothecin (CPT) was investigated. The structure and CPT loading properties of UiO-67-NH2 were assessed with the help of X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and high-performance liquid chromatography (HPLC). The XRD and SEM results indicated the successful synthesis of the nano-sized UiO-67-NH2. Further, FTIR spectroscopy indicated that UiO-67-NH2 could be loaded with CPT. Also, the HPLC experiments revealed that nano-sized UiO-67-NH2 shows high CPT loading capacity of up to 36.53 wt%.

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Acknowledgements

This work is supported by Guangxi Natural Science Foundation (No.2016GXNSFAA380063) and Guangxi Science Foundation (No. AD18126005).

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Authors and Affiliations

  1. Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi University for Nationalities, College of Chemistry and Chemical Engineering, Nanning, 530006, Guangxi, China

    DaoTong Chen, JiaRui Bi & Jian Wu

  2. Department of Chemistry, Faculty of Science, University of Lucknow, Lucknow, 226007, India

    Abhinav Kumar

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  1. DaoTong Chen
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  2. JiaRui Bi
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Correspondence to Jian Wu or Abhinav Kumar.

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Chen, D., Bi, J., Wu, J. et al. Zirconium Based Nano Metal–Organic Framework UiO-67-NH2 with High Drug Loading for Controlled Release of Camptothecin. J Inorg Organomet Polym 30, 573–579 (2020). https://doi.org/10.1007/s10904-019-01188-y

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