Synthesis of Large-Pore Silica Microspheres Using Dodecylamine as a Catalyst, Template and Porogen Agent


This paper reports a strategy combing a modified Stöber method and a post-hydrothermal treatment for the fabricating of silica microspheres with large pores. Dodecylamine (DDA), used as a catalyst, template and porogen agent, plays an important role in controlling both the particle morphology and the pore expansion. By adjusting the concentration of DDA (20, 40 and 80 mmol/L) and the temperature of hydrothermal treatment (80–140 °C), the pore size ranging from 3.5 to 16 nm could be obtained. The synthesized sub-2 µm silica spheres were modified with dimethyloctadecylchlorosilane (C18) and successfully applied for the separation of aromatic compounds in high-performance liquid chromatography (HPLC). The silica may be a good candidate as HPLC packing materials.

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This work was supported by the National Natural Science Foundation of China (Grant No. 21375038).

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Correspondence to Yanxiong Ke.

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Cheng, L., Cai, J. & Ke, Y. Synthesis of Large-Pore Silica Microspheres Using Dodecylamine as a Catalyst, Template and Porogen Agent. J Inorg Organomet Polym 29, 1417–1421 (2019).

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  • Dodecylamine
  • Sol–gel process
  • Mesoporous silica spheres
  • HPLC