Synthesis, Structure and In Vitro Anti-gastric Cancer Activity of Two New Mixed-Ligand Cu(II) and Cd(II)-Coordination Polymers

Abstract

By using a strategy of introducing two organic ligands with different donor groups, two new Cu(II) and Cd(II) coordination polymers (CPs) [Cu3(OH)(pz)3(Hpz)(H2O)(ipa)](H2O)4 (1, Hpz = pyrazol, H2ipa = isophthalic acid) and [Cd(phen)(ndc)](H2O) (2, phen = 1,10-phenanthroline, H2ndc = 1,2-naphthalene dicarboxylic acid) are synthesized and characterized. The molecular structures of the as-prepared CPs were determined by the single crystal X-ray diffraction (SCXRD) studies and their phase purities have been confirmed via the power X-day diffraction analysis (PXRD). The Cu(II)-based complex 1 is composed of trinuclear Cu33-OH)(pz)3 clusters that extended by the ipa2− ligands into a 1D left-handed helical chain along the c axis. In complex 2, the ndc2− ligands connect with the binuclear Cd2 unit along the c axis to shape a 1D chain-like structure, which is further stacked into a 2D layered network via π–π stacking. The as-prepared two CPs transformed to the nanoscale regime by mechanical grinding to yield nano 1 and nano 2 with excellent water dispersibility, maintaining its crystallinity. In addition, the in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay were conducted on the gastric cancer cell line AGS with increasing concentrations of the two nanosized CPs, which reveal their promising anticancer activity.

This is a preview of subscription content, log in to check access.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

References

  1. 1.

    J. Reedijk, Eur. J. Inorg. Chem. 2009, 1303–1312 (2009)

    Article  Google Scholar 

  2. 2.

    W.I. Sundquist, S.J. Lippard, Coord. Chem. Rev. 100, 293–322 (1990)

    CAS  Article  Google Scholar 

  3. 3.

    E.R. Jamieson, S.J. Lippard, Chem. Rev. 99, 2467–2498 (1999)

    CAS  Article  Google Scholar 

  4. 4.

    S. Richardson, Int. J. Pharm. 178, 231–243 (1999)

    CAS  Article  Google Scholar 

  5. 5.

    J.Y. Lu, Coord. Chem. Rev. 246, 327–347 (2003)

    CAS  Article  Google Scholar 

  6. 6.

    C.W. Duan, L.X. Hu, J.L. Ma, J. Mater. Chem. A 6, 6309–6318 (2018)

    CAS  Article  Google Scholar 

  7. 7.

    Y. Feng, H. Fan, Z. Zhong, H. Wang, D. Qiu, Inorg. Chem. 55, 11987–11992 (2016)

    CAS  Article  Google Scholar 

  8. 8.

    Y. Feng, M. Li, H. Fan, Q. Huang, D. Qiu, H. Shi, Dalton Trans. 44, 894–897 (2015)

    CAS  Article  Google Scholar 

  9. 9.

    S. Mukherjee, S. Ganguly, K. Manna, S. Mondal, S. Mahapatra, D. Das, Inorg. Chem. 57, 4050–4060 (2018)

    CAS  Article  Google Scholar 

  10. 10.

    B.M. Zeglis, V. Divilov, J.S. Lewis, J. Med. Chem. 54, 2391–2398 (2011)

    CAS  Article  Google Scholar 

  11. 11.

    Y.H. Liu, A. Li, J. Shao, C.Z. Xie, X.Q. Song, W.G. Bao, J.Y. Xu, Dalton Trans. 45, 8036–8049 (2016)

    CAS  Article  Google Scholar 

  12. 12.

    S.S. Bhat, A.A. Kumbhar, H. Heptullah, A.A. Khan, V.V. Gobre, S.P. Gejji, V.G. Puranik, Inorg. Chem. 50, 545–558 (2011)

    CAS  Article  Google Scholar 

  13. 13.

    T. Karmakar, Y. Kuang, N. Neamati, J.B. Baruah, Polyhedron 54, 285–293 (2013)

    CAS  Article  Google Scholar 

  14. 14.

    N. Zhang, Y. Fan, Z. Zhang, J. Zuo, P. Zhang, Q. Wang, S. Liu, C. Bi, Inorg. Chem. Commun. 22, 68–72 (2012)

    Article  Google Scholar 

  15. 15.

    B. Afzalian Mend, M. Delavar, M. Darroudi, J. Mol. Struct. 1134, 599–605 (2017)

    CAS  Article  Google Scholar 

  16. 16.

    G.M. Sheldrick, Acta Crystallogr. Sect. C 71, 3–8 (2015)

    Article  Google Scholar 

  17. 17.

    D. Chen, W. Shi, P. Cheng, Chem. Commun. 51, 370–372 (2015)

    CAS  Article  Google Scholar 

  18. 18.

    J.F. Ma, J. Yang, G.L. Zheng, J.F. Li, Liu, Inorg. Chem. 42, 7531–7534 (2003)

    CAS  Article  Google Scholar 

  19. 19.

    A.L. Spek, Acta Crystallogr. Sect. C 71, 9–18 (2015)

    CAS  Article  Google Scholar 

  20. 20.

    D. Sun, L.L. Han, S. Yuan, Y.K. Deng, M.Z. Xu, D.F. Sun, Cryst. Growth Des. 13, 377–385 (2013)

    CAS  Article  Google Scholar 

  21. 21.

    G. Liu, Y. Chen, X. Wang, B. Chen, H. Lin, J. Solid State Chem. 182, 566–573 (2009)

    CAS  Article  Google Scholar 

  22. 22.

    T. Kundu, S. Mitra, P. Patra, A. Goswami, D. Díaz Díaz, R. Banerjee, Chemistry 20, 10514–10518 (2014)

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Xiao-Long Wan.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Wan, X., Dong, L., Wang, J. et al. Synthesis, Structure and In Vitro Anti-gastric Cancer Activity of Two New Mixed-Ligand Cu(II) and Cd(II)-Coordination Polymers. J Inorg Organomet Polym 29, 1184–1191 (2019). https://doi.org/10.1007/s10904-019-01081-8

Download citation

Keywords

  • Coordination polymers
  • Mixed-linker
  • Mechanical grinding
  • MTT assay