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Emerging Opportunities in the Biomedical Applications of Dendrimers

Abstract

The medical field remains challenged with many unmet needs, prompting rigorous research for solutions. Dendrimers are emerging as innovative solutions to many unmet clinical needs. Indeed, commercial dendrimer-enabled gene transfection technologies exist and work is ongoing to translate many other dendrimer products into the market to assist patients. Here, we review the ongoing work on dendrimer-enabled drug delivery technologies, diagnostic platforms, and antimicrobial agents. Our goal is to inspire the continuous exploration of the dendritic scaffold to address many issues in the biomedical landscape.

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Reproduced from Ref. [60] with permission of Macmillan Publishers Limited

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Reproduced from Ref. [66] with permission from Acta Materialia Inc. Published by Elsevier Ltd

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Reproduced from Ref. [72] with permission of the American Chemical Society

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Reproduced from Ref. [87] with permission from the American Chemical Society

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Reproduced from Ref. [90] with permission from The Royal of Society of Chemistry

Fig. 11

Reproduced from Ref. [107] with permission from Elsevier B.V

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Acknowledgements

We thank the Natural Sciences and Engineering Research Council of Canada for support.

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Correspondence to Alaa S. Abd-El-Aziz.

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This paper is dedicated to Professor George Newkome in recognition of his outstanding contribution to the field of dendrimers.

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Abd-El-Aziz, A.S., Agatemor, C. Emerging Opportunities in the Biomedical Applications of Dendrimers. J Inorg Organomet Polym 28, 369–382 (2018). https://doi.org/10.1007/s10904-017-0768-5

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Keywords

  • Dendrimers
  • Drug delivery
  • Biosensing
  • Bioimaging
  • Antimicrobial agents
  • Gene transfection