An Impedimetric Sensor Comprising Magnetic Nanoparticles–Graphene Oxide and Carbon Nanotube for the Electrocatalytic Oxidation of Salicylic Acid

  • Hanieh Derikvand
  • Azadeh Azadbakht


An effective and facile electrocatalytic oxidation approach for the determination of salicylic acid (SA) on the surface of Ni-2,3-pyrazine dicarboxylic acid (Ni-PDA)/Fe3O4 magnetic nanoparticles/graphene oxide (GO)/carbon nanotube (CNTs) modified carbon paste electrode was demonstrated in this article. The GO sheets and CNTs were interlinked by ultrafine Fe3O4 nanoparticles forming three dimensional (3D) architectures. The characterization of the nanocomposites was studied by scanning electron microscopy, energy-dispersive X-ray, X-ray diffraction, and wavelength-dispersive X-ray spectroscopy. The electrochemical performance of the Ni-PDA film and the parameters affecting its activity were also investigated by cyclic voltammetry, and electrochemical impedance spectroscopy. The data revealed that the modified electrode present considerable electrocatalytic activity toward SA oxidation. The effects of some parameters such as the different scan rates, pH, and SA concentrations were also evaluated to provide catalysis mechanism for SA oxidation at the surface of modified electrode. Furthermore, impedimetric studies showed that the fabricated electrode as the sensing element has a detection capability of 900 nM allowing the quantitative analysis of SA in the concentration range from 5.00 to 155 µM. Remarkable advantages of the prepared modified electrode such as low detection limit, wide linear range of concentration and high sensitivity make it as good sensor for the selective determination of SA.

Graphical Abstract


Salicylic acid Fe3O4 magnetic nanoparticles Graphene oxide Electrocatalytic oxidation 



The authors gratefully acknowledge the support of this work by the Khorramabad Branch, Islamic Azad University for financial support.


  1. 1.
    J.G. Manjunatha, B.E.K. Swamy, O. Gilbert, G.P. Mamatha, B.S. Sherigara, Electrochem. Sci. 5, 682 (2010)Google Scholar
  2. 2.
    Z. Wang, F. Ai, Q. Xu, Q. Yang, J.H. Yu, W.H. Huang, Y.D. Zhao, Colloids. Surf. B 76, 370 (2010)CrossRefGoogle Scholar
  3. 3.
    R.A. Medina, F.M.L. Cordova, O.P. Barrales, M.A. Diaz, Int. J. Pharm. 216, 95 (2001)CrossRefGoogle Scholar
  4. 4.
    Z. Kokot, K. Burda, J. Pharm. Biomed. Anal 18, 871 (1998)CrossRefPubMedGoogle Scholar
  5. 5.
    M.S. Marcelo, G.T. Marcello, J.P. Ronei, Talanta 68, 1707 (2006)CrossRefGoogle Scholar
  6. 6.
    F. Kees, D. Jehnich, H. Grobecker, J. Chromatogr. B 677, 172 (1996)CrossRefGoogle Scholar
  7. 7.
    J.F. Jena, Y.Y. Tsaia, T.C. Yang, J. Chromatogr. A 912, 39 (2001)CrossRefGoogle Scholar
  8. 8.
    T. Kakkar, M. Mayersohn, J. Chromatogr. B 718, 69 (1998)CrossRefGoogle Scholar
  9. 9.
    G.A. Rivas, J.M. Calatayud, Talanta 42, 1285 (1995)CrossRefPubMedGoogle Scholar
  10. 10.
    W. Sun, M. Yang, Y. Li, Q. Jiang, S. Liu, K. Jiao, J. Pharm. Biomed. 48, 1326 (2009)CrossRefGoogle Scholar
  11. 11.
    A. Azadbakht, M.B. Gholivand, S. Menati, Electrochim. Acta 78, 82 (2012)CrossRefGoogle Scholar
  12. 12.
    H. Razmi, A. Azadbakht, Electrochim. Acta 50, 2193 (2005)CrossRefGoogle Scholar
  13. 13.
    M.B. Gholivand, A. Azadbakht, Electrochim. Acta 50, 10044 (2011)CrossRefGoogle Scholar
  14. 14.
    A. Azadbakht, M.B. Gholivand, Electrochim. Acta 125, 9 (2014)CrossRefGoogle Scholar
  15. 15.
    A. Azadbakht, M.B. Gholivand, Electrochim. Acta 133, 82 (2014)CrossRefGoogle Scholar
  16. 16.
    A. Azadbakht, A.R. Abbasi, Z. Derikvand, Z. Karimi, Nano-Micro Lett. 7, 152 (2015)CrossRefGoogle Scholar
  17. 17.
    A. Azadbakht, A.R. Abbasi, Z. Derikvand, Z. Karimi, J. Electroanal. Chem. 757, 277 (2015)CrossRefGoogle Scholar
  18. 18.
    M. Doulache, A. Benchettara, J. Anal. Chem. 69, 51 (2014)CrossRefGoogle Scholar
  19. 19.
    S.M. Ghoreishi, F. Zeraatkar Kashani, A. Khoobi, M. Enhessari, J. Mol. Liq. 211, 970 (2015)CrossRefGoogle Scholar
  20. 20.
    M. Khan, E. Yilmaz, B. Sevinc, E. Sahmetlioglu, J. Shah, M. Rasul Jan, M. Soylak, Talanta 146, 130 (2015)CrossRefPubMedGoogle Scholar
  21. 21.
    H. Wang, H. Dai, Chem. Soc. Rev. 42, 3088 (2013)CrossRefPubMedGoogle Scholar
  22. 22.
    X. Zhou, Z. Dai, S. Liu, J. Bao, Y.G. Guo, Adv. Mater. 26, 3943 (2014)CrossRefPubMedGoogle Scholar
  23. 23.
    L. Zhang, G. Zhang, H.B. Wu, L. Yu, X.W. Lou, Adv. Mater. 25, 2589 (2013)CrossRefPubMedGoogle Scholar
  24. 24.
    W.S. Hummers, R.E. Offeman, J. Am. Chem. Soc. 80, 1339 (1958)CrossRefGoogle Scholar
  25. 25.
    Y. Kim, D. Kim, C.S. Lee, Phys. B 337, 42 (2003)CrossRefGoogle Scholar
  26. 26.
    G. Vaidyanathan, S. Sendhilnathan, R. Arulmurugan, J. Magn. Magn. Mater. 313, 293 (2007)CrossRefGoogle Scholar
  27. 27.
    J.A. Lopez, F. González, F.A. Bonilla, G. Zambrano, M.E. Gómez, Am. Metal. Mater. 30, 60 (2010)Google Scholar
  28. 28.
    S. Jahanbani, A. Benvidi, Mat. Sci. Eng. C 68, 1 (2016)CrossRefGoogle Scholar
  29. 29.
    A. Benvidi, S. Jahanbani, A. Akbari, H.R. Zare, J. Electroanal. Chem. 758, 68 (2015)CrossRefGoogle Scholar
  30. 30.
    E. Laviron, J. Electroanal. Chem. Interfacial Electrochem. 101, 19 (1979)CrossRefGoogle Scholar
  31. 31.
    A. Ciszewski, Electroanalysis 7, 1132 (1995)CrossRefGoogle Scholar
  32. 32.
    M.B. Gholivand, A. Pashabadia, A. Azadbakht, S. Menati, Electrochim. Acta 56, 4022 (2011)CrossRefGoogle Scholar
  33. 33.
    M.B. Gholivand, A. Azadbakht, Mat. Sci. Eng. C 32, 1955 (2012)CrossRefGoogle Scholar
  34. 34.
    G. Roslonek, J. Taraszewska, J. Electroanal. Chem. 325, 285 (1992)CrossRefGoogle Scholar
  35. 35.
    A.A.J. Torriero, J.M. Luco, L. Sereno, J. Raba, Talanta 62, 247 (2004)CrossRefPubMedGoogle Scholar
  36. 36.
    Z. Wang, F. Wei, S.Y. Liu, Q. Xu, J.Y. Huang, X.Y. Dong, J.H. Yu, Q. Yang, Y.D. Zhao, H. Chen, Talanta 80, 1277 (2010)CrossRefPubMedGoogle Scholar
  37. 37.
    W.D. Zhang, B. Xu, Y.X. Hong, Y.X. Yu, J.S. Ye, J.Q. Zhang, J. Solid. State. Electrochem. 14, 1713 (2010)CrossRefGoogle Scholar
  38. 38.
    J.A. Harrison, Z.A. Khan, J. Electroanal. Chem. 28, 131 (1970)CrossRefGoogle Scholar
  39. 39.
    F.W. Xie, A.A. Yu, Y.A. Cheng, R.B. Qi, Q.Y. Li, H.M. Liu, S.S. Zhang, Chromatographia 72, 1207 (2010)CrossRefGoogle Scholar
  40. 40.
    M. Doulachea, A. Benchettaraa, M. Trari, J. Anal. Chem. 69, 51 (2014)CrossRefGoogle Scholar
  41. 41.
    P.J. Tseng, C.Y. Wang, Z.Y. Huang, Y.Y. Zhuang, S.F. Fu, Y.W. Lin, Anal. Methods 6, 1759 (2014)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Department of Chemistry, Khorramabad BranchIslamic Azad UniversityKhorramabadIran

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