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Two Metal–Organic Frameworks with Pharmaceutical Ingredient Linker: Influence of pH and Temperature

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Abstract

Two new metal–organic frameworks of [Zn3(bdc)2(dfp)2]·2DMF (1) and [Zn3(bdc-NH2)2(dfp)2]·DMF (2) (H2bdc = 1,4-benzenedicarboxylic acid, H2bdc-NH2 = 2-amino-1,4-benzenedicarboxylic acid and Hdfp = deferiprone) have been used as matrices for the drug carrier of 5-fluorouracil (5-FU). Drug loading content and drug release behavior of 1–2 were studied. These results indicate that their adsorption capacities for 5-FU were 38.4 and 35.9 wt% for 1 and 2, respectively. The drug release behaviors of 1–2 at different pH values (40, 6.0 and 7.4) and different temperature (37 and 40 °C) were investigated. A structure-activity relationship strategy has been conducted with the aim of rationalizing the experimental drug uptakes and emphasizing the relevant chemical and structural features that significantly impact their encapsulation and releasing performances in 1–2.

Graphical Abstract

A structure-activity relationship strategy has been conducted with the aim of rationalizing the experimental drug uptakes and emphasizing the relevant chemical and structural features that significantly impact their encapsulation and releasing performances in 1–2.

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Acknowledgements

This work was partially supported by the grants from the National Natural Science Foundation of China (21201044), the Chinese Training Plan of Guangdong Province Outstanding Young Professors in Higher Education Institutions (Grant YQ2013084), Innovation Training Project of Guangdong Medical University (XJ105711445, 2015ZYDM005, 2015ZZDM007), College Students Innovation Training Project of Guangdong Province (201410571060, 201510571054, 2015010571048, 201510571076, 201410571053), the science and technology plan key projects of Dongguan (2012108101010) and Start the scientific research projects of Guangdong Medical University (B2014009), the Central Finance Fund to Develop Local Universities (The construction of Tumor Nano-pharmaceutics Innovative Team).

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    Authors and Affiliations

    1. School of Pharmacy, Guangdong Medical University, Dongguan, 523808, People’s Republic of China

      Fumei Li, Chuying Gu, Haohong Li, Jingwen Xu & Jianqiang Liu

    2. Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Dongguan, 523808, People’s Republic of China

      Jianqiang Liu

    3. School of Life Sciences, Tsinghua University, Beijing, 100084, China

      Jianqiang Liu

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    1. Fumei Li
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    Correspondence to Haohong Li or Jianqiang Liu.

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    Li, F., Gu, C., Li, H. et al. Two Metal–Organic Frameworks with Pharmaceutical Ingredient Linker: Influence of pH and Temperature. J Inorg Organomet Polym 27, 334–341 (2017). https://doi.org/10.1007/s10904-016-0475-7

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