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Synthesis and Structure of 1D Copper(II) Polymers with Dissymmetrical N,N′-Bis(substituted)oxamide Ligands: Cytotoxicity and DNA-Binding Property

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Abstract

Two one-dimensional copper(II) coordination polymers with different dissymmetrical N,N′-bis(substituted)oxamide ligands were synthesized, namely {[Cu2(dmaepox)(dabt)]pic·H2O}n (1) and {[Cu2(dmapob)(dabt)]NO3·0.6H2O}n (2), where H3dmaepox and H3dmapob stand for N-(2-carboxylatophenyl)-N′-[3-(methylamino)propyl]oxamidate and N-(2-carboxylatophenyl)-N′-[3-(dimethylamino)propyl]oxamidate, respectively, and dabt is 2‚2′-diamino-4‚4′-bithiazole. Polymer 1 was characterized by elemental analyses, IR and electronic spectra and single-crystal X-ray diffraction. The crystal structure reveals that polymer 1 consists of many binuclear copper(II) units bridged by cis-oxamide and carboxylate groups. The two copper(II) ions are located in square-planar and square-pyramidal coordination environments, respectively. The separations of the Cu(II) atoms bridged by oxamide and carboxylate groups are 5.2035(7) and 5.1196(7) Å, respectively. The crystal structure of polymer 2 has been reported in our previous paper. However, its relative properties were not studied. In order to compare the influence of different bridging ligands on the cytotoxicities and DNA-binding properties, the cytotoxicities and reactivities towards DNA of polymers 1 and 2 were investigated. The results suggest that the two polymers can interact with herring sperm DNA in the mode of intercalation with binding affinities following the order of 1 > 2, and this is consistent with their in vitro cytotoxicities.

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Acknowledgments

This project was supposed by the National Natural Science Foundation of China (No.21071133), the Natural Science Foundation of Qingdao City [No. 11-2-4-1-(9)gch)], and the Program for Changjiang Scholars and Innovative Research Team in University.

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Authors and Affiliations

  1. Marine Drug & Food Institute, Ocean University of China, Qingdao, 266003, Shandong, People’s Republic of China

    Lin-Lin Zhang & Yan-Tuan Li

  2. Key Laboratory of Marine Drug, Chinese Ministry of Education, Ocean University of China, Qingdao, People’s Republic of China

    Ling-Dong Wang & Zhi-Yong Wu

  3. College of Marine Life Science, Ocean University of China, Qingdao, 266003, People’s Republic of China

    Cui-Wei Yan

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  1. Lin-Lin Zhang
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  2. Ling-Dong Wang
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  3. Yan-Tuan Li
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Correspondence to Yan-Tuan Li or Cui-Wei Yan.

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Lin-Lin Zhang and Ling-Dong Wang contributed equally to this study.

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Zhang, LL., Wang, LD., Li, YT. et al. Synthesis and Structure of 1D Copper(II) Polymers with Dissymmetrical N,N′-Bis(substituted)oxamide Ligands: Cytotoxicity and DNA-Binding Property. J Inorg Organomet Polym 22, 1128–1138 (2012). https://doi.org/10.1007/s10904-012-9705-9

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