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In Vitro and In Vivo Characterization of Biodegradable Poly(organophosphazenes) for Biomedical Applications

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Abstract

The need and the growing interest in polymers as biomaterials have led to the synthesis of new polymers with a variety of physico-chemical properties. Biomedical application of such materials not only depends on their physical properties but also on biocompatibility and biodegradability. Polyphosphazenes are a family of ‘hybrid inorganic–organic polymers’ with inorganic elements in the backbone and organic side-groups. The polyphosphazenes constitute a family of greatly diverse performance materials with a broad spectrum of properties. The present review focuses on the biodegradable polyphosphazenes, their biocompatibility, and degradation behavior both in vitro and in vivo. This review also covers the use of biodegradable polyphosphazenes as controlled release devices.

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Acknowledgments

The authors gratefully acknowledge funding from the NIH (R01 EB004051 and R01 AR052536). Dr. Laurencin was the recipient of a Presidential Faculty Fellow Award from the National Science Foundation.

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  1. Department of Orthopaedic Surgery, University of Virginia, 400 Ray C. Hunt Drive, Suite 330, Charlottesville, VA, 22903, USA

    Sangamesh G. Kumbar, Syam Prasad Nukavarapu, Yusuf M. Khan, Lakshmi S. Nair & Cato T. Laurencin

  2. Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22908, USA

    Yusuf M. Khan & Cato T. Laurencin

  3. Department of Chemical Engineering, University of Virginia, Charlottesville, VA, 22904, USA

    Cato T. Laurencin

  4. Department of Chemistry, University of Virginia, Charlottesville, VA, 22903, USA

    Subhabrata Bhattacharyya

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Kumbar, S.G., Bhattacharyya, S., Nukavarapu, S.P. et al. In Vitro and In Vivo Characterization of Biodegradable Poly(organophosphazenes) for Biomedical Applications. J Inorg Organomet Polym 16, 365–385 (2006). https://doi.org/10.1007/s10904-006-9071-6

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