This study evaluates the feasibility of enrolling and retaining perinatal immigrant and U.S.-born Latinas in a laboratory-based study that includes the collection of biomarkers implicated in the development of postpartum depression. This prospective study followed Latinas from third trimester of pregnancy to 12 weeks postpartum. Women were enrolled during pregnancy and interviewed at 4, 8 and 12 weeks postpartum. Demographic information, depression status and breastfeeding practices were ascertained using validated Spanish- and English-measures. Blood samples were collected at the 8-week postpartum laboratory visit during infant feeding and pain testing. Feasibility was demonstrated with 85 % retention of the original 34 prenatal women enrolled in the study. The majority (88 %) of women enrolled attended the 8-week laboratory visit regardless of depression status. This is the first study to demonstrate feasibility of enrolling and retaining depressed and nondepressed perinatal immigrant and U.S.-born Latinas in biomedical research.
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The authors wish to thank the mothers and their infants who participated in this groundbreaking study. This study could not have been possible without their impressive commitment to our work. The authors would also like to acknowledge the hard work of our impressive research assistants and technical staff: Kathryn McKenney, Sierra Pierce, Jayme Wood, Mala Elam, and Chihiro Christmas. The authors also wish to thank the National Institute of Mental Health (5T32MH093315-03; Drs. Girdler & Rubinow, PIs and MH085165-01A1; Dr. Meltzer-Brody), the Foundation of Hope for Research and Treatment of Mental Illness, and the North Carolina Translational and Clinical Sciences (NC TraCS) Institute for their support of this research. The project described here was also supported by Grants UL1TR000083, KL2TR000084, and TL1TR000085 from the National Center for Advancing Translational Sciences, National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Conflict of interest
Dr. Meltzer-Brody has received research Grant support from Sage Therapeutics.
All procedures performed in this study involving human participants were in accordance with the ethical standards of the University of North Carolina at Chapel Hill Internal Review Board and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Lara-Cinisomo, S., Plott, J., Grewen, K. et al. The Feasibility of Recruiting and Retaining Perinatal Latinas in a Biomedical Study Exploring Neuroendocrine Function and Postpartum Depression. J Immigrant Minority Health 18, 1115–1123 (2016). https://doi.org/10.1007/s10903-016-0391-5
- Perinatal women
- Postpartum depression
- Biomedical study