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A Review of Barriers to Minorities’ Participation in Cancer Clinical Trials: Implications for Future Cancer Research

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Abstract

To enhance nurses’ awareness and competencies in practice and research by reporting the common barriers to participation of minorities in cancer clinical trials and discussing facilitators and useful strategies for recruitment. Several databases were searched for articles published in peer reviewed journals. Some of the barriers to minorities’ participation in clinical trials were identified within the cultural social-context of cancer patients. The involvement of community networking was suggested as the most effective strategy for the recruitment of minorities in cancer clinical trials. Using culturally sensitive approaches to enhance ethnic minorities’ participation is important for advancing cancer care and eliminating health disparities. Awareness of barriers and potential facilitators to the enrollment of ethnic minority cancer patients may contribute to enhancing nurses’ competencies of recruiting ethnic minorities in nursing research, playing efficient roles in cancer clinical trials team, and providing culturally competent quality care.

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References

  1. Adams-Campbell LL, Ahaghotu C, Gaskins M, Dawkins FW, Smoot D, Polk OD, et al. Enrollment of African Americans onto clinical treatment trials: study design barriers. J Clin Oncol. 2004;22(4):730–4. doi:10.1200/JCO.2004.03.160.

    Article  PubMed  Google Scholar 

  2. American Cancer Society. Cancer facts & figures 2012. Retrieved on June 15, 2013 from http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-031941.pdf.

  3. American Cancer Society. Cancer facts & figures 2013. Retrieved on June 15, 2013 from http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-036845.pdf.

  4. Biedrzycki BA. Research information knowledge, perceived adequacy, and understanding in cancer clinical trial participants. Oncol Nurs Forum. 2011;38(4):291–6.

    Article  Google Scholar 

  5. CDC. Leading causes of death. 2012. Retrieved on November 22, 2012 from http://www.cdc.gov/nchs/fastats/lcod.htm.

  6. Epstein RM, Street RL Jr. Patient-centered communicationin cancer care: promoting health and reducing suffering. Bethesda: National Cancer Institute; 2007.

    Google Scholar 

  7. Ford GJ, Howerton WM, Lai YG, Gary LT, Bolen S, Gibbons CM, et al. Barriers to recruiting underrepresented populations to cancer clinical trials: a systematic review. Cancer. 2008;112(2):228–42. doi:10.1002/cncr.23157.

    Article  PubMed  Google Scholar 

  8. Grunfeld E, Zitzelsberger L, Coristine M, Aspelund F. Barriers and facilitators to enrollment in cancer clinical trials qualitative study of the perspectives of clinical research associates. Cancer. 2002;95(7):1577–83.

    Article  PubMed  Google Scholar 

  9. Giuliano AR, Mokuau N, Hughes C, Tortolero-Luna G, Risendal B, Ho RCS, Prewitt TE, et al. Participation of minorities in cancer research: the influence of structural, cultural, and linguistic factors. Ann Epidemiol. 2000;10(8):S22–34.

    Article  CAS  PubMed  Google Scholar 

  10. Health People 2020. Disparities. 2012. Retrieved on August 6, 2013 from http://healthypeople.gov/2020/about/DisparitiesAbout.aspx.

  11. Holmes DR, Major J, Lyonga ED, Alleyne RS, Clayton SM. Increasing minority patient participation in cancer clinical trials using oncology nurse navigation. Am J Surg. 2012;203:415–22. doi:10.1016/j.amjsurg.2011.02.005.

    Article  PubMed  Google Scholar 

  12. Horstmann E, McCabe MS, Grochow L, Yamamoto S, Rubenstein L, Budd T, et al. Risks and benefits of phase 1 oncology trials, 1991 through 2002. N Engl J Med. 2005;352:895–904. doi:10.1056/NEJMsa042220.

    Article  CAS  PubMed  Google Scholar 

  13. Howerton WM, Gibbons C, Baffi RC, Gary LT, Lai YG, Bolen S, Ford GJ. Provider roles in the recruitment of underrepresented populations to cancer clinical trials. Cancer. 2007;109(3):465–76. doi:10.1002/cncr.22436.

    Article  PubMed  Google Scholar 

  14. Hussain-Gambles M, Atkin K, Leese B. Why ethnic minority groups are under-represented in clinical trials: a review of the literature. Health Soc Care Community. 2004;12:382–8.

    Article  PubMed  Google Scholar 

  15. Ibrahim S, Sidani S. Strategies to recruit minority persons: a systematic review. J Immigr Minority Health. 2013. doi:10.1007/s10903-013-9783-y.

    Google Scholar 

  16. Klamerus JF, Bruinooge SS, Ye X, Klamerus ML, Damron D, Lansey D, Lowery JC, et al. The impact of insurance on access to cancer clinical trials at a comprehensive cancer center. Clin Cancer Res. 2010;16(24):5997–6003. doi:10.1158/1078-0432.CCR-10-1451.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Knobf MT, Juarez G, Lee S-YK, Sun V, Sun Y, Haozous E. Challenges and strategies in recruitment of ethnically diverse populations for cancer nursing research. Oncol Nurs Forum. 2007;34(6):1187–94.

    Article  PubMed  Google Scholar 

  18. Lai GY, Gary TL, Tilburt J, Bolen S, Baffi C, Wilson RF, Howerton MW, et al. Effectiveness of strategies to recruit underrepresented populations into cancer clinical trials. Clin Trials. 2006;3(2):133–41.

    Article  PubMed  Google Scholar 

  19. Lara NP, Hidgon R, Lim N, Kwan K, Tanaka M, Lau DH, Wun T, et al. Prospective evaluation of cancer clinical trial accrual patterns: Identifying potential barriers to enrollment. J Clin Oncol. 2001;19(6):1728–33.

    PubMed  Google Scholar 

  20. Lee Y-H, Salman A, Wang F. Recruiting Chinese-American adolescents to HIV/AIDS related research: a lesson learned from a cross-sectional study. Appl Nurs Res. 2012;23(1):40–6. doi:10.1016/j.apnr.2010.02.001.

    Article  Google Scholar 

  21. Lin JS, Finlay A, Tu A, Gany FM. Understanding immigrant Chinese Americans’ participation in cancer screening and clinical trials. J Commun Health. 2005;30(6):451–66. doi:10.1007/s10900-005-7280-5.

    Article  Google Scholar 

  22. Lubejko B, Good M, Weiss P, Schmieder L, Leos D, Daugherty P. Oncology clinical trials nursing: developing competencies for the novice. Clin J Oncol Nurs. 2011;15(6):637–43. doi:10.1188/11.CJON.637-643.

    Article  PubMed  Google Scholar 

  23. Mais K. The role of the research nurse in hospital-based oncology clinical trials. Nursing. 2006; 1 3: 22–3. Retrieved on December 25, 2013 from http://www.oncologynews.biz/pdf/oct_nov/ON_ON06_19.pdf.

  24. McCaskill-Stevens W, McKinney M, Whitman C, Minasian L. increasing minority participation in cancer clinical trials: the minority-based community clinical oncology program experience. J Clin Oncol. 2005;23(22):5247–54.

    Article  PubMed  Google Scholar 

  25. Murthy VH, Krumholz HM, Gross CP. Participation in cancer clinical trials race-, sex-, and age-based disparities. J Am Med Assoc. 2004;291(22):2720–6.

    Article  CAS  Google Scholar 

  26. National Cancer Institution. Cancer health disparities. 2013. Retrieved on June 13, 2013 from http://www.cancer.gov/cancertopics/disparities.

  27. National Cancer Institution. Raising awareness about cancer clinical trials in multicultural communities. 2013. Retrieved on June 13, 2013 from http://www.cancer.gov/cancertopics/disparities/lifelines/2013/clinicaltrials-hisp-english.pdf.

  28. National Cancer Institution. Cancer clinical trials. 2013. Retrieved on August 10, 2013 from http://www.cancer.gov/cancertopics/factsheet/clinicaltrials/clinical-trials.

  29. Oncology Nursing Society (ONS). Oncology clinical trials nurse competences. 2010. Retrieved on August 13, 2013 from http://www2.ons.org/media/ons/docs/publications/ctncompetencies.pdf.

  30. Paterniti AD, Chen SM, Chiechi C, Beckett AL, Horan N, Turrell C, Smith L, et al. Asian Americans and cancer clinical trials: a mixed-methods approach to understanding awareness and experience. Cancer. 2005;104(12):3015–24. doi:10.1002/cncr.21522.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Park E, Weiss E, Moy B. Recruiting and enrolling minority patients to cancer clinical trials. Commun Oncol. 2007;4(4):254–7.

    Article  Google Scholar 

  32. Pierce R, Chadiha LA, Vargas A, Mosley M. Prostate cancer and psychosocial concerns in African American men: literature synthesis and recommendations. Health Soc Work. 2003;28(4):302–11.

    Article  PubMed  Google Scholar 

  33. Phillips J, Weekes D. Incorporating multiculturalism into oncology nursing research: the last decade. Oncol Nurs Forum. 2002;29(5):808–16.

    Article  Google Scholar 

  34. Raghavan D. Disparities in cancer care: challenges and solutions. Oncology. 2007;21:493–6.

    PubMed  Google Scholar 

  35. Robey RR. An introduction to clinical trials. ASHA Lead. 2005, May 24. Retrieved on August 10, 2013 from http://www.asha.org/Publications/leader/2005/050524/f050524a.htm.

  36. Salman A, McCabe D, Easter T, Callahan B, Goldstein D, Smith TD, et al. Cultural competence among staff nurses who participated in a family-centered geriatric care program. J Nurses Staff Dev. 2007;23(3):103–11.

    Article  PubMed  Google Scholar 

  37. Salman A, Lee YH, Cooksey-James T. Chapter 2: emerging populations and health. In: Edelman CL, Mandle CL, editors. Health promotion throughout the life span. 8th ed. St. Louis: Mosby Elsevier; 2013.

    Google Scholar 

  38. Siegel R, Naishadham D, Jemal A. Cancer statistics. Cancer J Clin. 2012;62:10–29. doi:10.3322/caac.20138.

    Article  Google Scholar 

  39. Schmotzer GL. Barriers and facilitators to participation of minorities in clinical trials. Ethn Dis. 2012;22:226–30.

    PubMed  Google Scholar 

  40. Symonds RP, Lord K, Mitchell AJ, Raghavan D. Recruitment of ethnic minorities into cancer clinical trials: experience from the front lines. Br J Cancer. 2012;107:1017–21. doi:10.1038/bjc.2012.240.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Tenorio SL, Gamito EJ, Ogden S, Quintela J, Ordonez E, Crawford ED, Lamerato LE. A special program to increase the participation of Hispanics in prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial. Hisp Health Care Int. 2011;9(1):13–21. doi:10.1891/1540-4153.9.1.13.

    Article  Google Scholar 

  42. Tu S, Chen H, Chen A, Lim J, May S, Drescher C. Clinical trials: understanding and perceptions of female Chinese-American cancer patients. Cancer. 2005;104(S12):2999–3005. doi:10.1002/cncr.21524.

    Article  PubMed  PubMed Central  Google Scholar 

  43. US Department of Health and Human Services. NIH fact sheets—health disparities. 2013. Retrieved on June 13, 2013 from http://report.nih.gov/NIHfactsheets/ViewFactSheet.aspx?csid=124.

  44. Ulrich CM, Zhou Q, Ratcliffe SJ, Ye L, Grady C, Watkins-Bruner D. Nurse practitioners’ attitudes about cancer clinical trials and willingness to recommend research participation. Contemp Clin Trials. 2011;33(1):76–84. doi:10.1016/j.cct.2011.09.005.

    Article  PubMed  Google Scholar 

  45. Weckstein JD, Thomas AC, Emery FI, Shea FB, Fleury A, White EM, Pilar C. Assessment of perceived cost to the patient and other barriers to clinical trial participation. J Oncol Pract. 2011;7(5):330–3. doi:10.1200/JOP.2011.000236.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Wells AA, Zebrack B. Psychosocial barriers contributing to the under-representation of racial/ethnic minorities in cancer clinical trials. Soc Work Health Care. 2008;46(2):1–14. doi:10.1300/J010v46n02_01.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Faculty of Health Studies, Brandon University, Brandon, MB, R7A 6A9, Canada

    Ali Salman

  2. Inova Mount Vernon Hospital, Alexandria, VA, 22306, USA

    Claire Nguyen

  3. College of Nursing and Health, Wright State University-Miami Valley, 3640 Colonel Glenn Hwy., Dayton, OH, 45435-0001, USA

    Yi-Hui Lee

  4. School of Nursing, Ohio University, Athens, OH, 45701, USA

    Tawna Cooksey-James

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  1. Ali Salman
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  2. Claire Nguyen
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  4. Tawna Cooksey-James
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Correspondence to Yi-Hui Lee.

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Salman, A., Nguyen, C., Lee, YH. et al. A Review of Barriers to Minorities’ Participation in Cancer Clinical Trials: Implications for Future Cancer Research. J Immigrant Minority Health 18, 447–453 (2016). https://doi.org/10.1007/s10903-015-0198-9

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  • DOI: https://doi.org/10.1007/s10903-015-0198-9

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