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A Cluster-Randomized Trial to Evaluate a Mother–Daughter Dyadic Educational Intervention for Increasing HPV Vaccination Coverage in American Indian Girls

Abstract

We evaluated whether delivering educational presentations on human papillomavirus (HPV) to American Indian mothers affected HPV vaccination rates in their adolescent daughters. In March–April 2012, we recruited Hopi mothers or female guardians with daughters aged 9–12 years for a cluster-randomized intervention study on the Hopi Reservation. Participants attended mother-daughter dinners featuring educational presentations for mothers on either HPV (intervention) or juvenile diabetes (control) and completed baseline surveys. Eleven months later, we surveyed mothers on their daughters’ HPV vaccine uptake. We also reviewed aggregated immunization reports from the Indian Health Service to assess community-level HPV vaccination coverage from 2007 to 2013. Ninety-seven mother-daughter dyads participated; nine mothers reported that their daughters completed the three-dose HPV vaccination series before recruitment. Among the remaining mothers, 63 % completed the follow-up survey. Adjusting for household income, the proportion of daughters completing vaccination within 11 months post-intervention was similar in the intervention and control groups (32 vs. 28 %, adjusted RR = 1.2, 95 % confidence interval (CI) 0.6–2.3). Among unvaccinated daughters, those whose mothers received HPV education were more likely to initiate vaccination (50 vs. 27 %, adjusted RR = 2.6, 95 % CI 1.4–4.9) and complete three doses (adjusted RR = 4.0, 95 % CI 1.2–13.1) than girls whose mothers received diabetes education. Community-level data showed that 80 % of girls aged 13–17 years and 20 % of girls aged 11–12 completed the vaccination series by 2013. HPV vaccine uptake in Hopi girls aged 13–17 years is significantly higher than the U.S. national average. Brief educational presentations on HPV delivered to American Indian mothers might increase HPV vaccination rates in daughters aged 9–12 years.

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Acknowledgments

The National Cancer Institute had no involvement in the study design; collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. We are grateful to the Hopi and Tewa women who participated in this project, and to the Hopi Tribal Council and Lorencita Joshweseoma for their support. We thank Phyllis Winans at the Hopi Health Care Center for her assistance in extracting the community-level HPV vaccination data; we thank Carey Onsae at the Hopi Health Care Center for her assistance leading the health activity for daughters attending the dinners; we thank our local project coordinators, Olivia Dennis and Lorene Vicente, for their coordination efforts; and we thank our community advisors, Carrie Watahomagie, Lisa Lomavaya, and Marilyn Fredericks, for their input and advice. For editing the final manuscript, we also thank Raymond Harris.

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Correspondence to Rachel L. Winer.

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Funding

This research was performed under the auspices of the Collaborative to Improve Native Cancer Outcomes, a P50 program project sponsored by the National Cancer Institute (Grant No. 1P50CA148110).

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The authors declare that they have no conflict of interest.

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For the Collaborative to Improve Native Cancer Outcomes (CINCO).

The members of the Collaborative to Improve Native Cancer Outcomes includes D. Buchwald, D.R. Flum, E.M. Garroutte, A.A. Gonzales, J.A. Henderson, P. Nez Henderson, D.L. Patrick, S.P. Tu, and R.L. Winer.

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Winer, R.L., Gonzales, A.A., Noonan, C.J. et al. A Cluster-Randomized Trial to Evaluate a Mother–Daughter Dyadic Educational Intervention for Increasing HPV Vaccination Coverage in American Indian Girls. J Community Health 41, 274–281 (2016). https://doi.org/10.1007/s10900-015-0093-2

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  • DOI: https://doi.org/10.1007/s10900-015-0093-2

Keywords

  • Human papillomavirus (HPV)
  • American Indian/Alaska Native (AI/AN)
  • Vaccination
  • Intervention
  • Education