Journal of Community Health

, Volume 39, Issue 6, pp 1193–1199 | Cite as

Prevalence and Profile of Ophthalmic Disorders in Oculocutaneous Albinism: A Field Report from South-Eastern Nigeria

  • N. N. Udeh
  • B. I. Eze
  • S. N. Onwubiko
  • O. C. Arinze
  • E. N. Onwasigwe
  • R. E. Umeh
Original Paper


To assess the burden and spectrum of refractive and non-refractive ophthalmic disorders in south-eastern Nigerians with oculocutaneous albinism. In a population-based survey in Enugu state, between August, 2011 and January, 2012, albinos were identified using the database of the Enugu state’s Albino Foundation, and mass media-based mobilisation. The participants were enrolled at the Eye Clinics of the University of Nigeria Teaching Hospital and Enugu State University of Science and Technology Teaching Hospital using a defined protocol. Relevant socio-demographic and clinical data were obtained from each participant. Descriptive and comparative statistics were performed. Statistical significance was indicated by p < 0.05. The participants (n = 153; males, 70) were aged 23.5 + 10.4 SD years (range 6–60 years). Both refractive and non-refractive disorders were present in all participants. Non-refractive disorders comprised nystagmus, foveal hypoplasia, hypopigmented fundi and prominent choroidal vessels in 100.0 % participants; and strabismus in 16.3 % participants. Refractive disorders comprised astigmatism −73.2 % eyes, myopia −23.9 % and hypermetropia 2.9 %. Spherical refractive errors ranged from −14.00 DS to +8.00 DS while astigmatic errors ranged from −6.00 DC to +6 DC. Mixed refractive and non-refractive disorder i.e. presenting visual impairment was present in 100.0 % participants. Overall, refractive error was associated with non-possession of tertiary education (OR 0.61; 95 % CI 0.38–0.96; p = 0.0374). There is high prevalence of refractive, non-refractive and mixed ophthalmic disorders among albinos in south-eastern Nigeria. This underscores the need for tailored provision of resources to address their eye care needs, and creation of needs awareness amongst them.


Albinism Refractive Non-refractive Disorder Nigeria 



The authors acknowledge the assistance of the Albino Foundation (TAF) Enugu State Chapter, Drs. Oguama Felix, Okeh Ada, Eze Joy N, Ogbonnaya O and Dr. Ama for logistic support. The authors declare no external funding support for this work.

Conflict of interest

None declared.


  1. 1.
    Karen, G., Jakob, E. K., & Karen, B. (2007). Oculocutaneous albinism. Orphanet Journal of Rare Diseases, 2, 43.CrossRefGoogle Scholar
  2. 2.
    Oetting, W. S., & King, R. A. (1999). Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism. Human Mutation, 13(2), 99–115.PubMedCrossRefGoogle Scholar
  3. 3.
    Hong, E. S., Zeeb, H., & Repacholl, M. H. (2006). Albinism in Africa as a public health issue. BMC Public Health, 6, 212.PubMedCentralPubMedCrossRefGoogle Scholar
  4. 4.
    Kromberg, J. G., & Jenkins, T. (1982). Prevalence of albinism in the South African Negro. South African Medical Journal, 61(11), 383–386.PubMedGoogle Scholar
  5. 5.
    Okoro, A. N. (1975). Albinism in Nigeria. British Journal of Dermatology, 92(5), 485–492.PubMedCrossRefGoogle Scholar
  6. 6.
    King, R. A., Lewis, R. A., Townsend, D., Zelickson, A., Olds, D. P., & Brumbaugh, J. (1985). Brown oculocutaneous albinism. Ophthalmology, 92, 1496–1505.PubMedCrossRefGoogle Scholar
  7. 7.
    Larkin, D. F. P., & O’Donoghue, H. N. (1988). Developmental glaucoma in oculocutaneous albinism. Ophthalmic Genetics, 9(1), 1–4.CrossRefGoogle Scholar
  8. 8.
    The Physics Encyclopedia: Albinism: Physics Daily. Accessed December 28, 2010.
  9. 9.
    Anderson, J., Lavoie, J., Merill, K., King, R. A., & Summer, C. G. (2004). Efficacy of spectacles in persons with albinism. J AAPOS, 8(6), 515–520.PubMedCrossRefGoogle Scholar
  10. 10.
    Oduntan, A. O., Raliavhegwa, M., & Lund, P. M. (2002). Vision status of children with oculocutaneous albinism. Ophthalmic and Physiological Optics, 22, 572–573.CrossRefGoogle Scholar
  11. 11.
    Sacharowitz, H. (2000). An overview of oculocutaneous albinism in South Africa. In C. Steven, et al. (Eds.), Visual rehabilitation: assessment, intervention, and outcomes (pp. 41–46). New York: Swets and Zeitlinger Publishers.Google Scholar
  12. 12.
    Mvogo, C. E., Bella-Hiag, A. L., Ellong, A., & Mbarga, B. M. (1999). Visual problems in albinos: a hospital study carried out at the Douala General Hospital. Santé, 9(2), 89–91.PubMedGoogle Scholar
  13. 13.
    Wildsoet, C. F., Oswald, P. J., & Simon, C. (2000). Albinism: its implication for refractive development. Investigative Ophthalmology & Visual Science, 41(1), 1–7.Google Scholar
  14. 14.
    Preising, M. N., Forster, H., Gonser, M., & Lorenz, B. (2011). Screening of TYR, OCA2, GPR143, and MC1R in patients with congenital nystagmus, macular hypoplasia, and fundus hypopigmentation indicating albinism. Molecular Vision, 17, 939–948.PubMedCentralPubMedGoogle Scholar
  15. 15.
    Abadi, R., & Eve, P. (1989). The recognition and management of albinism. Ophthalmic and Physiological Optics, 9(1), 3–15.PubMedCrossRefGoogle Scholar
  16. 16.
    Udeh NN, Eze BI, Onwubiko SN, Arinze OC, Onwasigwe EN, Umeh RE. Oculocutaneous Albinism: Identifying and Overcoming Barriers to Vision Care in a Nigerian Population. Journal of Community Health. 2013 Nov 6. [Epub ahead of print].Google Scholar
  17. 17.
    Kutzbach, B. R., Merrill, K. S., Houge, K. M., Downes, S. J., Holleschan, A. M., MacDonald, J. T., et al. (2009). Evaluation of vision-specific-quality-of-life in albinism. Journal of AAPOS, 13(2), 191–195.PubMedCrossRefGoogle Scholar
  18. 18.
    Mohamed, A. F., El-Sayed, N. S., & Seifeldin, N. S. (2010). Clinico-epidemiologic features of oculocutaneous albinism in northeast section of Cairo—Egypt. Egyptian Journal of Medical Human Genetics, 11, 167–172.CrossRefGoogle Scholar
  19. 19.
    Wolf, B. A., Rubin, S. E., & Kodsi, S. R. (2005). Comparison of clinical findings in pediatric patients with albinism and different amplitudes of nystagmus. Journal of AAPOS, 9, 363–368.PubMedCrossRefGoogle Scholar
  20. 20.
    Summer, C. G. (2009). Albinism: classification, clinical characteristics and recent findings. Optometry and Vision Science, 86, 659–662.CrossRefGoogle Scholar
  21. 21.
    2006 Population and Housing Census of the Federal Republic of Nigeria. Official Gazette of Federal Republic of Nigeria, 96(2), 2009.Google Scholar
  22. 22.
    Collins, B., & Silver, J. (1990). Recent experiences in management of visual impairment in Albinism. Ophthalmic Genetics, 11(3), 225–228.CrossRefGoogle Scholar
  23. 23.
    Kromberg, J. G., Castle, D., Zwane, E. M., & Jenkins, T. (1989). Albinism and skin cancer in Southern Africa. Clinical Genetics, 36, 43–52.PubMedCrossRefGoogle Scholar
  24. 24.
    King, R. A., Creel, D., Cervenka, J., et al. (1980). Albinism in Nigeria with delineation of new recessive oculocutaneous type. Clinical Genetics, 17, 259–270.PubMedCrossRefGoogle Scholar
  25. 25.
    Cullinan, T. R. (1977). The epidemiology of visual disability. Studies of visually disabled people in the community. HSRU Report, 28, 136–137.Google Scholar
  26. 26.
    National Organization of Albinism and Hypopigmentation (NOAH). Information for parent and children with Albinism. Accessed December 28, 2010.
  27. 27.
    Ezeilo, B. N. (1989). Psychological aspects of albinism: an exploratory study of Nigerian (Igbo) albino subjects. Social Science and Medicine, 29(9), 1129–1131.PubMedCrossRefGoogle Scholar
  28. 28.
    Yahalom, C., Tzur, V., Blumenfeld, A., Greifner, G., Eli, D., Rosenmann, A., et al. (2012). Refractive profile in oculocutaneous albinism and its correlation with final visual outcome. British Journal of Ophthalmology, 96(4), 537–539.PubMedCrossRefGoogle Scholar
  29. 29.
    Watkins, S. (1972). Albinism in Nigeria. Lancet, 1, 203.CrossRefGoogle Scholar
  30. 30.
    Merrill, K. S., Lavoie, J. D., King, R. A., & Summers, C. G. (2004). Positive angle kappa in albinism. Journal of AAPOS, 8, 237–239.PubMedCrossRefGoogle Scholar
  31. 31.
    Merrill, K., Hogue, K., Downes, S., Holleschau, A. M., Kutzbach, B. R., MacDonald, J. T., et al. (2011). Reading acuity in albinism: Evaluation with MNREAD charts. Journal of AAPOS, 15, 29–32.PubMedCrossRefGoogle Scholar
  32. 32.
    Lee, K. A., King, R. A., & Summers, C. G. (2001). Stereopsis in patients with albinism: clinical correlates. Journal of Pediatric Ophthalmology and Strabismus, 5, 98–104.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • N. N. Udeh
    • 1
  • B. I. Eze
    • 1
  • S. N. Onwubiko
    • 1
  • O. C. Arinze
    • 2
  • E. N. Onwasigwe
    • 1
  • R. E. Umeh
    • 1
  1. 1.Department of OphthalmologyUniversity of Nigeria Teaching HospitalEnuguNigeria
  2. 2.Department of OphthalmologyFederal Teaching HospitalAbakalikiNigeria

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