Pathological Gambling Induced by Dopamine Antagonists: A Case Report
Pathological gambling is defined as inappropriate, persistent, and maladaptive gambling behaviour. It is a non-pharmacological addiction classified as an impulse control disorder. However, pathological gambling has been associated with dopamine agonist use. Here we report of a 28-year-old man with a first major depressive episode and a post-traumatic stress disorder who has been treated with a combination of the serotonine/noradrenaline reuptake inhibitor duloxetine and the tricyclic antidepressant maprotiline. The administration of antipsychotic flupentixole (up to 7 mg) turned this slight online poker gambler into an excessive gambler. Only after the discontinuation of the antidopaminergic agents and the switch to bupropion did this gambling behaviour stop which suggests a causal relationship between dopamine antagonists and pathological gambling.
KeywordsAntipsychotic agents Gambling behaviour Dopamine antagonists
Conflict of interest
- Miura, J., Kikuchi, A., Fujii, A., Tateishi, T., & Kaneko, S. (2009). Pathological gambling associated with cabergoline in a case of recurrent depression. Drug Discoveries & Therapeutics, 3(4), 190–192.Google Scholar