Journal of Genetic Counseling

, Volume 26, Issue 3, pp 379–386 | Cite as

Clinical Cancer Genetics Disparities among Latinos

  • Marcia Cruz-Correa
  • Julyann Pérez-Mayoral
  • Julie Dutil
  • Miguel Echenique
  • Rafael Mosquera
  • Keila Rivera-Román
  • Sharee Umpierre
  • Segundo Rodriguez-Quilichini
  • Maria Gonzalez-Pons
  • Myrta I. Olivera
  • Sherly Pardo
  • on behalf of the Puerto Rico Clinical Cancer Genetics Consortia
Review Paper


The three major hereditary cancer syndromes in Latinos (Hereditary Breast and Ovarian Cancer, Familial Adenomatous Polyposis and Lynch Syndrome) have been shown to exhibit geographic disparities by country of origin suggesting admixture-based disparities. A solid infrastructure of clinical genetics geared towards diagnosis and prevention could aid in reducing the mortality of these cancer syndromes in Latinos. Currently, clinical cancer genetic services in Latin America are scarce. Moreover, limited studies have investigated the mutational spectrum of these cancer syndromes in Latinos resulting in gaps in personalized medicine affecting diagnosis, treatment and prevention. The following commentary discusses available genotype and clinical information on hereditary cancer in Latinos and highlights the limited access for cancer genetic services in Latin America including barriers to genetic testing and alternatives for providing better access to genetic services. In this review, we discuss the status of clinical genetic cancer services for both US Latinos and those Latinos living in Latin America.


Genetic testing Genetic counseling Health disparities Hereditary cancer Hispanics 



This work was supported by grant number U54CA096297 and grant number 1U54CA163071-01A1. Furthermore, we want to thank the support of the Puerto Rico Clinical and Translational Research Consortium (8U54MD007587-03).

Compliance with Ethical Standards

Conflict of interest

No conflicts of interest disclosures from the authors and state compliance with all ethical standards.

Human Studies and Informed Consent

This article does not contain any studies with human participants performed by any of the authors.

Animal Studies

This article does not contain any animal studies by any of the authors.


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Copyright information

© National Society of Genetic Counselors, Inc. 2016

Authors and Affiliations

  • Marcia Cruz-Correa
    • 1
    • 2
  • Julyann Pérez-Mayoral
    • 1
    • 2
  • Julie Dutil
    • 3
  • Miguel Echenique
    • 4
  • Rafael Mosquera
    • 5
  • Keila Rivera-Román
    • 6
  • Sharee Umpierre
    • 1
  • Segundo Rodriguez-Quilichini
    • 1
  • Maria Gonzalez-Pons
    • 1
    • 2
  • Myrta I. Olivera
    • 1
    • 2
  • Sherly Pardo
    • 7
  • on behalf of the Puerto Rico Clinical Cancer Genetics Consortia
  1. 1.Division of Cancer BiologyUniversity of Puerto Rico Comprehensive Cancer CenterSan JuanUSA
  2. 2.Department of MedicineUniversity of Puerto Rico School of MedicineSan JuanUSA
  3. 3.Ponce Research InstitutePonce Health Sciences UniversityPonceUSA
  4. 4.Cancer CenterAuxilio Mutuo HospitalSan JuanUSA
  5. 5.Puerto Rico Gastroenterology AssociationSan JuanUSA
  6. 6.Department of PediatricsUniversity of Puerto Rico School of MedicineSan JuanUSA
  7. 7.Department of PathologyUniversity of Puerto Rico School of MedicineSan JuanUSA

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