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Furan-Dihydroquinazolinone Based Fluorescent Nanoprobe for Selective Recognition of 4-Nitrophenol: A Spectofluorimetric Approach

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Abstract

Fluorescent organic nanoparticles (FONPs) have attracted much attention as a practicable and effective platform for detection applications. The present article describes the preparation of FONPs derived from the quinazolinone-based 2-(furan-2-yl)-2,3-dihydroquinazolin-4(1H)-one derivative FHDQ. Self-assembly of FHDQ in an aqueous medium resulted in the formation of FONPs through H-type aggregation and showed excellent fluorescence properties. The presence of other coexisting species solutions did not affect the selective fluorescence quenching observed with the addition of 4-nitrophenol (4-NP). The photophysical properties, i.e., UV-Vis absorbance, fluorescence emission, and lifetime measurements together with zeta particle sizer, support excited-state complex formation followed by a dynamic fluorescence quenching phenomenon in the emission of FDHQNPs. In the concentration range of 0 to 36 μg.\({\mathrm{mL}}^{-1}\), the detection limit of this turn-off sensor FDHQNPs against 4-NP was determined to be 0.01611 μM. Finally, the practicability of the FDHQNPs for the analysis of 4-NP in environmental samples was demonstrated.

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Acknowledgements

The authors are thankful to the Department of Chemistry, Shivaji University, Kolhapur, India, for providing all necessary infrastructural and instrumental facilities. The author SBW thanks The Director, Directorate of Technical Education, Government of Maharashtra, for granting permission for Ph.D. research work.

Funding

Govind B. Kolekar thanks to National Research Foundation of Korea (NRF) BP Grant No.: 2019H1D3A2A01057526.

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Author notes

  1. Saubai B. Wakshe and Pravin R. Dongare equally contributed to this work.

Authors and Affiliations

  1. Fluorescence Spectroscopy Research Laboratory, Department of Chemistry, Shivaji University, Kolhapur, 416004, MS, India

    Saubai B. Wakshe, Pravin R. Dongare, Prashant V. Anbhule & Govind B. Kolekar

  2. Tarsadia Institute of Chemical Science, Uka Tarsadia University, Bardoli, 394350, Gujarat, India

    Anil H. Gore

  3. D. Y. Patil Agriculture and Technical University, Talsande, Kolhapur, 416112, MS, India

    Gurunath V. Mote

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  1. Saubai B. Wakshe
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Contributions

Saubai B. Wakshe, Pravin R. Dongare: Methodology, Writing- original draft. Gurunath V. Mote, Prashant V. Anbhule: Formal analysis. Anil H. Gore, Govind B. Kolekar: Conceptualization, Methodology, Writing- review & editing, Formal analysis, Investigation, Supervision.

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Correspondence to Govind B. Kolekar.

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Wakshe, S.B., Dongare, P.R., Gore, A.H. et al. Furan-Dihydroquinazolinone Based Fluorescent Nanoprobe for Selective Recognition of 4-Nitrophenol: A Spectofluorimetric Approach. J Fluoresc 34, 321–332 (2024). https://doi.org/10.1007/s10895-023-03267-3

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