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Utilization of Localized Surface Plasmon Resonance of Silver Nanoparticles for the Spectrofluorimetric Estimation of Oxymetazoline in Dosage Forms: Application to Aqueous Humor

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Abstract

A simple, novel, cost-effective and highly sensitive spectrofluorimetric method was developed for estimation of the nasal decongestant oxymetazoline (OMZ) whether per se or in its pharmaceutical preparations using colloidal silver nanoparticles (AgNPs). The method is based on the high catalytic potential activity of AgNPs on the fluorescence intensity of OMZ leading to 12-fold increase in its fluorescence intensity. The response was linear over the range of 20.0 to 700.0 ng/mL with lower detection limit of 5.0 ng/mL and limit of quantification of 14.0 ng/mL. The proposed method was applied to the assay of commercial nasal drops, nasal spray and synthetic aqueous humor. Interference likely to be encountered from co-administered drugs was studied. The developed method was optimized and validated as per International Council of Harmonization (ICH). An explanation for the drug-AgNPs interaction was proposed.

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References

  1. Alaqad K, Saleh TA (2016) Gold and silver nanoparticles: synthesis methods, characterization routes and applications towards drugs. J Environ Anal Toxicol 6:525–2161

    Article  Google Scholar 

  2. Jouyban A, Rahimpour E (2020) Optical sensors based on silver nanoparticles for determination of pharmaceuticals: an overview of advances in the last decade. Talanta 217:121071

    Article  CAS  Google Scholar 

  3. Willets KA, Van Duyne RP (2007) Localized surface plasmon resonance spectroscopy and sensing. Annu Rev Phys Chem 58:267–297

    Article  CAS  Google Scholar 

  4. Khodaveisi J, Shabani AMH, Dadfarnia S, Moghadam MR, Hormozi-Nezhad MR (2015) Simultaneous determination of protocatechuic aldehyde and protocatechuic acid using the localized surface plasmon resonance peak of silver nanoparticles and chemometric methods. Quím Nova 38:896–901

    CAS  Google Scholar 

  5. El-Zahry MR (2018) A localized surface plasmon resonance sensing method for simultaneous determination of atenolol and amiloride in pharmaceutical dosage forms and urine samples. J Anal Methods Chem 2018:1–9

    Article  CAS  Google Scholar 

  6. Alarfaj N, Altamimi S, El-Tohamy M, Almahri A (2019) Exploitation of localized surface plasmon resonance of silver/gold nanoparticles for the fluorescence quantification of angiotensin II receptor antagonists in their tablets and bio-samples. New J Chem 43:492–503

    Article  CAS  Google Scholar 

  7. Moffat AC, Osselton MD, Widdop B, Galichet LY (2011) Clark’s analysis of drugs and poisons in pharmaceuticals, body fluids and postmortem material, vol II, 4th edn. The Pharmaceutical Press, London

    Google Scholar 

  8. Sweetman S (2014) Martindale: the complete drug reference, 38th edn. The Pharmaceutical Press, London

    Google Scholar 

  9. Whalen K (2018) Lippincott illustrated reviews: pharmacology. Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  10. The United States Pharmacopoeia 34 (2011) The National Formulary 29. The US Pharmacopoeial Convention, Rockville

    Google Scholar 

  11. The British Pharmacopoeia (2019) Her Majesty’s stationary office. The British Pharmacopoeia, London

    Google Scholar 

  12. The European Pharmacopoeia 7 (2011) Council of Europe: European directorate for the quality of medicines and healthcare. The European Pharmacopoeia 7, Strasbourg

    Google Scholar 

  13. Al-Sabha TAN, Rasheed BA (2011) Spectrophotometric determination of oxymetazoline hydrochloride based on the oxidation reactions. Jordan J Chem 146:1–9

    Google Scholar 

  14. Zakaria SA (2011) Spectrophotometric determination of oxymetazoline hydrochloride via oxidative coupling reaction with 4-aminoantipyrine in the presence of potassium periodate. Rafidain J Sci 22:97–108

    Article  Google Scholar 

  15. Abdel-Aziz O, El-Kosasy A, Magdy N, El Zahar N (2014) Novel spectroscopic methods for determination of cromolyn sodium and oxymetazoline hydrochloride in binary mixture. Spectrochim Acta A 131:59–66

    Article  CAS  Google Scholar 

  16. Hegazy MAM, Al-Ghobashy MA, Eltanany BM, Khattab FI (2015) Spectral resolution and simultaneous determination of oxymetazoline hydrochloride and sodium cromoglycate by derivative and ratio-based spectrophotometric methods. Eur J Chem 6:319–324

    Article  CAS  Google Scholar 

  17. Othman NS, Fathe SA (2013) Indirect spectrophotometric determination of oxymetazoline hydrochloride. Rafidain J Sci 24:84–95

    Article  Google Scholar 

  18. Abdulsattar JO, Hadi H, Richardson S, Iles A, Pamme N (2020) Detection of doxycycline hyclate and oxymetazoline hydrochloride in pharmaceutical preparations via spectrophotometry and microfluidic paper-based analytical device (μPADs). Anal Chim Acta 1136:196–204

    Article  CAS  Google Scholar 

  19. Salama F, Abdel-Salam K, Abdel-Halim A, Said R, Madkour A (2018) Validated spectrofluorimetric method for the determination of oxymetazoline hydrochloride via derivatization with 4-chloro-7-nitrobenzo-2-oxa-1, 3-diazole (NBD-Cl). Eurasian J Anal Chem 13:4

    Article  CAS  Google Scholar 

  20. Yu X, Liu H, Yang Y, Lu S, Yao Q, Yi P (2013) The investigation of the interaction between oxymetazoline hydrochloride and mucin by spectroscopic approaches. Spectrochim Acta A 103:125–129

    Article  CAS  Google Scholar 

  21. Boon P, Sudds W (1967) The gas chromatographic determination of imidazolines in pharmaceutical preparations. J Pharm Pharmacol 19(Suppl):88S

    Google Scholar 

  22. Massaccesi M (1987) Gas chromatographic determination of some imidazolines in pharmaceutical preparations using the FFAP in stationary phase. Pharm Acta Helv 62:302

    PubMed  CAS  Google Scholar 

  23. Hoffmann T, Thompson R, Seifert J (1989) Determination of the nasal decongestant, oxymetazoline hydrochloride, in pharmaceutical formulations by HPLC. Drug Dev Ind Pharm 15:743–757

    Article  CAS  Google Scholar 

  24. Stanisz B, Nowinski W (2000) Determination of oxymetazoline hydrochloride and decomposition products by high-performance liquid chromatography. Acta Pol Pharm 57:399–402

    PubMed  CAS  Google Scholar 

  25. Sudsakorn S, Kaplan L, Williams DA (2006) Simultaneous determination of triamcinolone acetonide and oxymetazoline hydrochloride in nasal spray formulations by HPLC. J Pharm Biomed Anal 40:1273–1280

    Article  CAS  Google Scholar 

  26. Shaikh KA, Patil AT (2013) Stability-indicating HPLC method for the determination of mometazone furoate, oxymetazoline, phenyl ethanol and benzalkonium chloride in nasal spray solution. J Trace Anal Food Drugs 1:14–21

    Google Scholar 

  27. Hegazy MA, Al-Ghobashy MA, Eltanany BM, Khattab FI (2015) Validated chromatographic methods for the simultaneous determination of sodium cromoglycate and oxymetazoline hydrochloride in a combined dosage form. J Adv Chem 11:3850

    Article  CAS  Google Scholar 

  28. Fathy M, Abo El Abass Mohamed S, Elmansi H, Belal F (2016) Simultaneous determination of cromolyn sodium combined dosage forms using isocratic HPLC method. J Chromatogr Sci 55:14–22

    Article  CAS  Google Scholar 

  29. Garcı́a-Campaña AM, Sendra JMB, Vargas MPB, Baeyens WR, Zhang X (2004) Flow injection analysis of oxymetazoline hydrochloride with inhibited chemiluminescent detection. Anal Chim Acta 516:245–249

    Article  CAS  Google Scholar 

  30. Wang NN, Shao YQ, Tang YH, Yin HP, Wu XZ (2009) Flow-injection chemiluminescence method for the determination of naphazoline hydrochloride and oxymetazoline hydrochloride. J Lumin 24:178–182

    Article  CAS  Google Scholar 

  31. Chen Q, Li P, Yang H, Li B, Zhu J, Peng L (2010) Nonaqueous capillary electrophoresis conditions for the simultaneous separation of eight alpha-adrenergic blocking agents. Anal Bioanal Chem 398:937–942

    Article  CAS  Google Scholar 

  32. Abdel-Raoof AM, Abdel-Monem AH, Almrasy AA, Mohamed TF, Nasr ZA, Mohamed GF (2020) Optimization of highly sensitive screen printed electrode modified with cerium (IV) oxide nanoparticles for electrochemical determination of oxymetazoline hydrochloride using response surface methodology. J Electrochem Soc 167:047502

    Article  CAS  Google Scholar 

  33. Munir A, Bozal-Palabiyik B, Khan A, Shah A, Uslu B (2019) A novel electrochemical method for the detection of oxymetazoline drug based on MWCNTs and TiO2 nanoparticles. J Electroanal Chem 844:58–65

    Article  CAS  Google Scholar 

  34. Mavani K, Shah M (2013) Synthesis of silver nanoparticles by using sodium borohydride as a reducing agent. Int J Eng Res Technol 2:1–5

    Google Scholar 

  35. Martins JM, Farinha A (1998) Uniformity of dosage units—comparative study of methods and specifications between Eur. Pharm. 3rd and USP 23. J Pharm Biomed 18:487–495

    Article  CAS  Google Scholar 

  36. Tashkhourian J, Hormozi-Nezhad M, Khodaveisi J (2011) Application of silver nanoparticles and principal component-artificial neural network models for simultaneous determination of levodopa and benserazide hydrochloride by a kinetic spectrophotometric method. Spectrochim Acta A 82:25–30

    Article  CAS  Google Scholar 

  37. Leiterer J, Delissen F, Emmerling F, Thünemann A, Panne U (2008) Structure analysis using acoustically levitated droplets. Anal Bioanal Chem 391:1221–1228

    Article  CAS  Google Scholar 

  38. Tobiszewski M, Namieśnik J (2017) Greener organic solvents in analytical chemistry. Curr Opin Green Sustain 5:1–4

    Article  Google Scholar 

  39. Georges J (1993) Lanthanide-sensitized luminescence and applications to the determination of organic analytes. A review. Analyst 118:1481–1486

    Article  CAS  Google Scholar 

  40. I.S. Committee (1996) ICH harmonised tripartite guidelines. Validation of analytical procedures: methodology Q2. In: International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use

  41. Miller J, Miller JC (2018) Statistics and chemometrics for analytical chemistry. Pearson education, London

    Google Scholar 

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Funding

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Authors and Affiliations

  1. Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt

    Shymaa M. Abd Elhaleem, Fawzi Elsebaei, Shereen Shalan & Fathalla Belal

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  1. Shymaa M. Abd Elhaleem
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  2. Fawzi Elsebaei
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  3. Shereen Shalan
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  4. Fathalla Belal
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Contributions

SMAE: methodology, formal analysis, validation, investigation, writing–original draft. FE: validation, writing–review & editing, supervision. SS: validation, writing–review & editing, supervision. FB: conceptualization, validation, writing–review & editing, resources, supervision.

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Correspondence to Shymaa M. Abd Elhaleem.

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Abd Elhaleem, S.M., Elsebaei, F., Shalan, S. et al. Utilization of Localized Surface Plasmon Resonance of Silver Nanoparticles for the Spectrofluorimetric Estimation of Oxymetazoline in Dosage Forms: Application to Aqueous Humor. J Fluoresc 31, 1871–1881 (2021). https://doi.org/10.1007/s10895-021-02812-2

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  • DOI: https://doi.org/10.1007/s10895-021-02812-2

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