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Multi-step Synthesis, Characterization and Photophysical Investigation of Novel Biologically Active Heterocyclic Chalcone (AECO)

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A Correction to this article was published on 07 August 2023

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Abstract

Novel alkylated heterocyclic chalcone (E)-1-(2-(allyloxy)phenyl)-3-(9-ethyl-9H-carbazol-3-yl)prop-2-en-1-one (AECO) with extended π-bond was prepared by the multi-steps synthesis. The structure of the AECO was established by the spectroscopic technics and purity of the compound was confirmed by the elemental analysis. Physicochemical parameters of the AECO such as molar absorption coefficient, transition dipole moments, stokes shift, oscillator strength and fluorescence quantum yield were calculated in ten various solvents on the basis of polarity of the solvents to see the effect of the solvent with AECO. Interaction of the AECO chromophore with cationic CTAB and anionic SDS surfactants were determined by using the fluorescence spectroscopy techniques. The intensity of the florescence spectrum increase with increasing the concentrations of surfactants. This suggests that strong interaction occurs between AECO with surfactants and this interaction arise from electrostatic forces. So, AECO chromophore could be used as analysis to define the Critical Micelle Concentration (CMC) of the surfactants. In addition the in-vitro antibacterial active of novel heterocyclic chalcone agents four bacteria’s strain were evaluated and result showed AECO is beater antibacterial agent against Gram-Negative Bacteria (E. coli and S. flexneri) as compare to the Gram Negative Bacteria with respected to the standard drug Tetracycline.

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All data generated or analyzed during this study are included in this article article (as figures and tables).

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Acknowledgements

This work was supported by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, Saudi Arabia for technical and financial support.

Funding

This work was supported by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, under grant No. (G: 186–130-1441). The author, therefore, acknowledge with thanks DSR for technical and financial support.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, King Abdul-Aziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia

    Mohie E. M. Zayed, Khalid Ahmed Alzahrani & Salman A. Khan

  2. Physical Section, School of Sciences, Maulana Azad National Urdu University, Hyderabad, 500032, Telangana, India

    Salman A. Khan

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  1. Mohie E. M. Zayed
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  2. Khalid Ahmed Alzahrani
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  3. Salman A. Khan
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All authors equally contributed.

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Correspondence to Mohie E. M. Zayed or Salman A. Khan.

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The original online version of this article was revised: An error in referring to the project number. The project number should be G: 186–130-1441 and Not G: 488–130-1440 as stated.

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Zayed, M.E.M., Alzahrani, K.A. & Khan, S.A. Multi-step Synthesis, Characterization and Photophysical Investigation of Novel Biologically Active Heterocyclic Chalcone (AECO). J Fluoresc 31, 1823–1831 (2021). https://doi.org/10.1007/s10895-021-02780-7

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