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Two Zn(II)-based Coordination Polymers: Fe3+ Ion and Prevention Activity Detection On Postpartum Hemorrhage By Regulating Anticoagulant Factor Activity

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Abstract

Two new Zn(II)-based coordination polymers {[Zn3(L1)6(H2O)]∙(H2O)4}n (1, HL1 = 4-(tetrazol-5-yl)phenyl-4,2′:6′,4″-terpyridine) and [Zn2Cl2(L2)2H2O]n (2, HL2 = 4-([2,2′:6’,2″’-terpyridin]-4′-yl)benzoic acid) have been successfully prepared using two similar organic ligands with distinct donor groups under similar reaction conditions. The distinct structural features and donor atoms make the two complexes show different water stability, and the complex 1 with good water stability, which can be utilized as the sensor for Fe3+ ion detection in water. The value of Stern–Volmer quenching constant of 1 to the Fe3+ is 5.77 × 104 M− 1, which lies in the top region of the reported CP-based sensors. The mechanism investigation reveals that the energy transfer of resonance from the complex 1 to the Fe3+ ion can account for its fluorescent quenching behavior. The treatment activity of compounds 1 and 2 on the postpartum hemorrhage (PPH) was assessed. First, the cytotoxicity of compounds 1 and 2 on human umbilical vein endothelial cells was assessed with Cell Counting Kit-8 detection kit. Then, to evaluate the prevention of compounds 1 and 2 on the PPH, we conducted the Lowry method and detected the clotting factor IX and anticoagulant factor III contents after the indicated treatment. Finally, the inflammatory response in mice was determined by ELISA method, and the IL-6 and IL-8 levels were determined.

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Acknowledgements

This work was supported by grants from Medical Research Project of Chongqing Health and Family Planning Commission (2017MSXM031).

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Authors and Affiliations

  1. Gynaecology and Obstetrics, Chongqing General Hospital, Chongqing, China

    Xia Wu, Yu Wen, Xiao-Qing Tan, Miao Liang & Yan Qin

  2. Gynaecology and Obstetrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

    Xiao-Ling Gan

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  1. Xia Wu
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  2. Yu Wen
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Correspondence to Xiao-Ling Gan.

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Wu, X., Wen, Y., Tan, XQ. et al. Two Zn(II)-based Coordination Polymers: Fe3+ Ion and Prevention Activity Detection On Postpartum Hemorrhage By Regulating Anticoagulant Factor Activity. J Fluoresc 30, 1365–1374 (2020). https://doi.org/10.1007/s10895-020-02619-7

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  • DOI: https://doi.org/10.1007/s10895-020-02619-7

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