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Development of Facile and Selective Fluorescent Probe for Physiological Phosphates based on Aggregation-induced Emission

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Abstract

In this work, two new fluorescence chemosensors 2-(4-(1,2,2-triphenylvinyl)phenoxy) acetic acid (TPE-COOH) and 2,2’-(((1,2-diphenylethane-1,2-diyl)bis(4,1-phenylene))bis(oxy))diacetic acid (TPE-(COOH)2) were synthesized and applied for the facile detection of physiological phosphates. Due to the aggregation-induced emission (AIE) character, the emission can be turned on after label free interaction with polyethyleneimine (PEI). When the physiological phosphates were introduced to the system, the AIEgens/PEI complex was dissociated due to stronger electrostatic interaction between PEI and phosphates, which resulted in the significant fluorescence quenching of AIEgens. As the four kinds of phosphates cytidine-5’-diphosphate disodium salt (CDP), adenosine-5 (ADP), sodium pyrophosphate (PPi) and guanosine-5’-diphosphate disodium salt (GDP) had different interaction with PEI, also the TPE-COOH and TPE-(COOH)2 had different interaction with PEI, the fluorescence quenching effect was distinct for four phosphates. The unique pattern of fluorescence variations was differentiated by chemometric methods including principal component analysis and linear discriminant analysis. The robustness of the sensor array was proved by discrimination of four kinds of phosphates in serum samples with different concentrations, and the discrimination capacity was not influenced in complicated samples

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Funding

The authors greatly appreciate the Science and Technology Planning Project of Guangdong Province of China (2018B020208005), Social Science and Technology Development Key Project of Dongguan of China (2019507101162) and Central Public-interest Scientific Institution Basal Research Fund, CAFS (2019ZD0804).

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Authors and Affiliations

  1. School of Environment and Civil Engineering, Dongguan University of Technology, Dongguan, 523808, China

    Zhe Jiao

  2. Dongguan thonebio. Co. Ltd, Dongguan, 523003, China

    Zhe Jiao

  3. Dongguan Environmental Monitoring Centre, 523009, Dongguan, China

    Xiaojuan Long & Yingfang Lu

  4. Integrated Technology Centre of Dongguan Entry-Exit Inspection and Quarantine Bureau, 523073, Dongguan, China

    Zongning Guo & Xuelin Huang

  5. Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, 214081, Wuxi, China

    Chao Song

  6. Key Laboratory of Control of Quality and Safety for Aquatic Products, Ministry of Agriculture and Rural Affairs, Beijing, 100125, China

    Chao Song

Authors
  1. Zhe Jiao
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  2. Xiaojuan Long
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  3. Yingfang Lu
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  4. Zongning Guo
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  5. Xuelin Huang
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  6. Chao Song
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Correspondence to Zhe Jiao, Xuelin Huang or Chao Song.

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Jiao, Z., Long, X., Lu, Y. et al. Development of Facile and Selective Fluorescent Probe for Physiological Phosphates based on Aggregation-induced Emission. J Fluoresc 30, 1197–1202 (2020). https://doi.org/10.1007/s10895-020-02587-y

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  • DOI: https://doi.org/10.1007/s10895-020-02587-y

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