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Sensitive and Selective Detection of Antibiotic D-Penicillamine Based on a Dual-Mode Probe of Fluorescent Carbon Dots and Gold Nanoparticles

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Abstract

This paper reported a dual-mode probe for D-penicillamine on the basis of pH-mediated gold nanoparticles aggregation and fluorescence resonance energy transfer (FRET) from carbon dots. D-penicillamine is a zwitterionic compound and has different forms depending on specific pH ranges. The thiol group of D-penicillamine has high affinity towards the surface of gold nanoparticles and can replace other surface ligands. When pH values were close to its isoelectrical point (pH(I)), the D-penicillamine capped gold nanoparticles aggregated through hydrogen bonding or electrostatic interactions, resulting in the releasing of carbon dots from gold nanoparticles. The dual-mode probe consisted of fluorescent carbon dots and gold nanoparticles, and the fluorescence of carbon dots was quenched by the attached gold nanoparticles due to the FRET. Then, the fluorescence can be recovered in presence of D-penicillamine due to the gold nanoparticles aggregation in specific pH range. Under the optimum conditions, the probe has linear response for D-penicillamine in the 0.25–1.5 μM concentration range with a detection limit of 0.085 μM. This method provides a potential application in sensitive detection of D-penicillamine.

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Acknowledgements

The work was financially supported from the National Key Research and Development Program of China (2017YFA02070003), the National Natural Science Foundation of China (21475134, 21507135, 21675158, and 21775042) and the Fundamental Research Funds for the Central Universities (2016ZZD06).

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Authors and Affiliations

  1. College of Environmental Science and Engineering, North China Electric Power University, Beijing, 102206, China

    Hongwei Ge, Ji Yue, Long Yu, Xinfeng Chen, Tianxin Hou & Suhua Wang

  2. School of Chemistry and Chemical Engineering, Anhui University of Technology, Maanshan, 243032, China

    Kui Zhang

  3. Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, 230031, Anhui, China

    Huan Yu & Suhua Wang

  4. Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

    Khalid A. Alamry, Hadi M. Marwani & Suhua Wang

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  1. Hongwei Ge
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Ge, H., Zhang, K., Yu, H. et al. Sensitive and Selective Detection of Antibiotic D-Penicillamine Based on a Dual-Mode Probe of Fluorescent Carbon Dots and Gold Nanoparticles. J Fluoresc 28, 1405–1412 (2018). https://doi.org/10.1007/s10895-018-2307-3

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