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Anti-Prostate Cancer Activity of 8-Hydroxyquinoline-2-Carboxaldehyde–Thiosemicarbazide Copper Complexes by Fluorescent Microscopic Imaging

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Abstract

Copper 8-hydroxyquinoline-2-carboxaldehyde–thiosemicarbazide (CuHQTS) and copper 8-hydroxyquinoline-2-carboxaldehyde–4,4-dimethyl-3-thiosemicarbazide (CuHQDMTS) are two copper thiosemicarbazone complexes with potent anticancer activity on cisplatin-resistant neuroblastoma cells. This study aimed to evaluate anti-prostate cancer activity of these two copper complexes in vitro. Both CuHQTS and CuHQDMTS inhibited proliferation of prostate cancer cells and showed cytotoxicity on prostate cancer cells carrying green fluorescent protein (GFP) by fluorescent microscopic imaging. The findings of this study demonstrated anti-prostate cancer activity of CuHQTS and CuHQDMTS and suggested that GFP-carrying prostate cancer cells might be used for testing anticancer activity of copper complexes by fluorescent microscopic imaging.

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Acknowledgments

This study was supported by a faculty research development fund from Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, Texas, USA.

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Authors and Affiliations

  1. Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Fang Xie & Fangyu Peng

  2. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Fangyu Peng

  3. Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Fangyu Peng

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  1. Fang Xie
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  2. Fangyu Peng
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Correspondence to Fangyu Peng.

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Xie, F., Peng, F. Anti-Prostate Cancer Activity of 8-Hydroxyquinoline-2-Carboxaldehyde–Thiosemicarbazide Copper Complexes by Fluorescent Microscopic Imaging. J Fluoresc 27, 1937–1941 (2017). https://doi.org/10.1007/s10895-017-2133-z

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  • DOI: https://doi.org/10.1007/s10895-017-2133-z

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