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Synthesis, Structural, DNA Binding and Cleavage Studies of Cu(II) Complexes Containing Benzothiazole Cored Schiff Bases

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Abstract

Novel benzothiazole Schiff bases L1 [1-((4,6-difluorobenzo[d]thiazol-2-ylimino)methyl) naphthalen-2-ol], L2 [3-((4,6-difluorobenzo[d]thiazol-2-ylimino) methyl)benzene-1,2-diol], L3 [2-((4,6-difluorobenzo[d]thiazol-2-ylimino)methyl)-5-methoxyphenol], L4 [2-((4,6-difluorobenzo[d]thiazol-2-ylimino)methyl)-4-chlorophenol] and their binary Cu(II) complexes were synthesized. The structures of all the compounds have been discussed on the basis of elemental analysis, FT-IR, NMR, UV-Visible, ESI-Mass, TGA, ESR, SEM, powder XRD and magnetic moments. Based on the analytical and spectral data a square planar geometry has been assigned to all complexes in which the Schiff bases act as monobasic bidentate ligands, coordinating through the azomethine nitrogen and phenolic oxygen atom. DNA binding ability of these complexes was studied on CT-DNA by using UV-Vis absorption, fluorescence and viscometry. DNA cleavage ability of the complexes was examined on pBR322 DNA by using gel electrophoresis method. All the DNA binding studies reveal that they are good intercalators. The bioefficacy of the ligands and their complexes was examined against the growth of bacteria and fungi in vitro to evaluate their antimicrobial potential. The screening data revealed that the complexes showed more antimicrobial activity than the corresponding free ligands.

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Acknowledgments

We express our sincere thanks to the Head, Department of Chemistry for providing the necessary facilities. We are thankful to the Director, CFRD, Osmania University, Hyderabad, and the Director, IICT, Hyderabad, and the SAIF, IIT Bombay for providing spectral and analytical data. We are also thankful to DST-PURSE, DST-SERB and UGC-UPE (FAR) for providing financial assistance.

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  1. Department of Chemistry, Osmania University, Hyderabad, Telangana, -500007, India

    Somapangu Tejaswi, Marri Pradeep Kumar, Aveli Rambabu, Narendrula Vamsikrishna &  Shivaraj

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  1. Somapangu Tejaswi
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  2. Marri Pradeep Kumar
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  3. Aveli Rambabu
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Correspondence to Shivaraj.

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Tejaswi, S., Kumar, M.P., Rambabu, A. et al. Synthesis, Structural, DNA Binding and Cleavage Studies of Cu(II) Complexes Containing Benzothiazole Cored Schiff Bases. J Fluoresc 26, 2151–2163 (2016). https://doi.org/10.1007/s10895-016-1911-3

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