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2,6-Dansyl Azide as a Fluorescent Probe for Hydrogen Sulfide

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Abstract

A second-generation sulfonyl azide-based fluorescent probe, 2,6-DNS-Az, has been developed for the quantitative detection of H2S in aqueous media such as phosphate buffer and bovine serum. Compare to the first-generation 1,5-DNS-Az probe, this probe shows both high sensitivity in phosphate buffer without the need for addition of surfactant and selectivity for sulfide over other anions and biomolecules, and thus can be used as a useful tool for detection of H2S in the biological system.

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Acknowledgment

We are grateful for the financial support from Chinese Scholarship Council (KW), Molecular Basis of Disease for a fellowship (HP), and Center for Diagnostics and Therapeutics for a CDT/University fellowship (HP).

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Authors and Affiliations

  1. Department of Chemistry, Center for Diagnostics and Therapeutics, and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA, 30302-4098, USA

    Ke Wang, Hanjing Peng, Nanting Ni, Chaofeng Dai & Binghe Wang

Authors
  1. Ke Wang
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  2. Hanjing Peng
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  3. Nanting Ni
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  4. Chaofeng Dai
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  5. Binghe Wang
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Corresponding author

Correspondence to Binghe Wang.

Additional information

Ke Wang and Hanjing Peng contributed equally to this work.

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Wang, K., Peng, H., Ni, N. et al. 2,6-Dansyl Azide as a Fluorescent Probe for Hydrogen Sulfide. J Fluoresc 24, 1–5 (2014). https://doi.org/10.1007/s10895-013-1296-5

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  • DOI: https://doi.org/10.1007/s10895-013-1296-5

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