Abstract
The three Ru(II) complexes of [Ru(phen)2dppca]2+ (1) [Ru(bpy)2dppca]2+ (2) and [Ru(dmb)2dppca]2+ (3) (where phen = 1,10 phenanthroline, bpy = 2,2-bipyridine, dmb = 2 ,2-dimethyl 2′,2′-bipyridine and polypyridyl ligand containing a single carboxylate functionality dppca ligand (dipyridophenazine-11-carboxylic acid) have been synthesized and characterized. These complexes have been shown to act as promising calf thymus DNA intercalators and a new class of DNA light switches, as evidenced by UV-visible and luminescence titrations with Co2+ and EDTA, steady-state emission quenching by [Fe(CN)6]4− and KI, DNA competitive binding with ethidium bromide, viscosity measurements, and DNA melting experiments. The results suggest that 1, 2, and 3 complexes bind to CT-DNA through intercalation and follows the order 1 > 2 > 3. Under irradiation at 365 nm, the three complexes have also been found to promote the photocleavage of plasmid pBR322 DNA.
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We are grateful to UGC New Delhi for financial support and also grateful to G. Bhanuprakash reddy, Scientist-G, National Institute of Nutrition, Hyderabad for helping to record CD spectra.
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Yata, P.K., Shilpa, M., Nagababu, P. et al. Study of DNA Light Switch Ru(II) Complexes : Synthesis, Characterization, Photocleavage and Antimicrobial Activity. J Fluoresc 22, 835–847 (2012). https://doi.org/10.1007/s10895-011-1018-9
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DOI: https://doi.org/10.1007/s10895-011-1018-9