Skip to main content
SpringerLink
Log in

Estrous Cycle, Folliculogenesis, and Brain Catecholamines after Stimulation of the Sexual System by Choriogonadotropin in Female Minks Selected for Behavior

  • Comparative and Ontogenic Physiology
  • Published:
Journal of Evolutionary Biochemistry and Physiology Aims and scope Submit manuscript

Abstract

The content of hypothalamic dopamine (DA) and noradrenaline (NA) is determined and ovary function (folliculogenesis) in various states of estrous cycle is studied in non-selected (control) immature (7-month old) standard female minks and in similar females of aggressive and quiet behavioral types (the 18th generation of selection) in norm and at the 7th day after single intramuscular injections of chorionic gonadotropin (CG). At the 7th day after the CG administrations, the control females were distributed by their estrous cycle state as follows: anestrus (A)— 47.2%, anestrus-proestrus (AP)—10.0%, proestrus (P)—8.5%, proestrus-estrus (PE)—14.3%, and estrus (E)— 20.0%. In the female minks selected for behavior, there was a significant increase of percentage of estrous females: to 84.6% in the aggressive ( p < 0.001) and to 58.4% in the quiet type animals ( p < 0.01). The number of growing and maturing (at the early stage) follicles in intact females of aggressive behavior was lower than in control and in females of the quiet type. However, the number of Graafian vesicles in ovaries of aggressive and quiet females did not differ and exceeded control. The stimulation by CG enhanced the differences between the ovaries of selected animals. In control females at the 7th day after CG injections there was a tendency for a decrease of the DA and NA content with development of estrus (A→AP→P). The hypothalamic DA concentration was higher in intact females of the aggressive type than in the quiet females ( p < 0.05). In animals of the aggressive type, stimulation of the sex system decreased the DA level. No correlation between sexual function and DA and NA levels was found in females of the quiet type. However, differential analysis of NA in these females with different reactions of vaginal epithelium to CG stimulation (A, AP vs P, PE, E) indicates correlation of catecholamine level with sexual function. Thus, selection of minks for aggressive behavioral type produces an increase of the hypothalamic catecholamine level, which, in turn, is one of factors inhibiting sexual function.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Trut, L.N., Early Canid Domestication: the Farm-Fox Experiment, Am. Scientist, 1999, vol. 87, pp. 160–169.

    Article  Google Scholar 

  2. Shishkina, G.T., Borodin, P.M., and Naumenko, E.V., Sexual Maturation and Seasonal Changes in Plasma Levels of Sex Steroids and Fecundity of Wild Norway Rats Selected for Reduced Aggressiveness toward Humans, Physiol. Behav., 1993, vol. 53, pp. 389–393.

    Article  PubMed  Google Scholar 

  3. Klochkov, D.V., Trapezov, O.V., and Kharlamova, A.V., Effect of Selection of Minks Mustela vison for Behavior on Their Folliculogenesis and Reproductive Function, Zh. Evol. Biokhim. Fiziol., 1996, vol. 32, pp. 620–628.

    PubMed  Google Scholar 

  4. Trut, L.N., The Problem of Morphogenesis and Integrity in the Context of Destabilizing Selection, Genetika, 1987, vol. 23, pp. 974–987.

    PubMed  Google Scholar 

  5. Naumenko, E.V., Popova, N.K., and Ivanova, L.N., Neuroendocrine and Neurochemical Mechanisms of Animal Domestication, Genetika, 1987, vol. 23, pp. 1011–1025.

    PubMed  Google Scholar 

  6. Babichev, V.N., Neirogormonal’naya regulyatsiya ovarial’nogo tsikla (Neurohormonal Regulation of Ovarian Cycle), Moscow, 1984.

  7. Klochkov, D.V. and Eryuchenkov, P.A., On Stimulation of Mink Folliculogenesis and Reproductive Functions by Chorionic Gonadotropin, Sel’skokhoz. Biol., 2002, no. 4, pp. 97–104.

  8. Trapezov, O.V., Selection-Induced Transformations of the Defence Reaction to Hunabs in the American Mink (Mustela vison Schreb.), Genetika, 1987, vol. 23, pp. 1120–1127.

    PubMed  Google Scholar 

  9. Pedersen, T. and Peters, H., Proposal for a Classification of Oocytes and Follicles in the Mouse Ovary, J. Reprod. Fertil., 1968, vol. 17, pp. 555–557.

    Google Scholar 

  10. Schlumpf, M., Lichtensteiger, W., Langemann, H., Waser, P.G., and Hefti, F., A Fluorimetric Microtechnique for the Simultaneous Assay of 5-Hydroxytriptamine, Noradrenaline and Dopamine in Milligrams of Brain Tissue, Biochem. Pharmacol., 1974, vol. 23, pp. 2337–2346.

    Article  Google Scholar 

  11. Hammond, J., Gonadotropin-Induced Ovulation in Mink, J. Mammal., 1952, vol. 33, pp. 219–233.

    Google Scholar 

  12. Chang, M.C., Reciprocal Insemination and Egg Transfer between Ferrets and Mink, J. Exp. Zool., 1968, vol.168, pp. 49–59.

    Article  PubMed  Google Scholar 

  13. Douglas, L.A., Pierson, R.A., and Murphy, B.D., Ovarian Follicular Development in Mink (Mustela vison), J. Reprod. Fertil., 1994, vol. 100, pp. 583–590.

    PubMed  Google Scholar 

  14. Donovan, B.T. and Gledhill, B., Gonadal Steroids and the Control of Gonadal Function in Seasonally Breeding Species, Exp. Brain Res., 1981, vol. 42, pp. 158–168.

    PubMed  Google Scholar 

  15. Kruip, Th.A.M. and Dielman, S.J., Steroid Hormone Concentrations in the Fluid of Bovine Follicles Relative to Size, Quality and Stage of Oestrus Cycles, Theriogenol., 1985, vol. 24, pp. 395–408.

    Article  Google Scholar 

  16. Dyban, A.P. and Baranov, V., Oogenesis of Mammals. Problems of Developmental Biology, Sovremennye problemy oogeneza (Current Problems of Oogenesis), Moscow, 1977, pp. 200–233.

  17. Budantsev, A.Yu., Monoaminergicheskie sistemy mozga (Monoaminergic Brain Systems), Moscow, 1976.

  18. Meyerson, B.J., Malmnas, C.O., and Everitt, B.J., Neuropharmacology, Neurotransmitters and Sexual Behavior in Mammals, Handbook of Behavioral Neurobiology, 1985, vol. 7, pp. 495–536.

    Google Scholar 

  19. Babichev, V.N., Adamskaya, E.I., and Kuznetsova, T.A., Sex Hormones as Modulators of Mechanism of Action of Gonadoliberin and Gobadotropins in Regulation of the Reproductive System, 2-ya nauchn. konf. pamyati M.G. Kolnakova (The 2nd Scientific Conf. in Memory of M.G. Kolpakov), Abstracts, Novosibirsk, 2002, p. 15.

  20. Bertrand, F., Viguie, C., Picard, S., and Malpaux, B., Median Eminence Dopaminergic Activation Is Critical for the Early Long-Day Inhibition of Luteinizing Hormone Secretion in the Ewe, Endocrinology, 1998, vol. 139, pp. 5094–5102.

    Article  PubMed  Google Scholar 

  21. Pastorova, B., The Influence of Superovulation Preparations on the Levels of Catecholamines in Eminentia Mediana, the Pituitary and Pineal Gland of the Sheep, Physiol. Res., 1998, vol. 47, pp. 471–475.

    PubMed  Google Scholar 

  22. Nikulina, E.M., Trapezov, O.V., and Popova, N.K., Concentration of Monoamines in the Brain of Minks Differing in Their Reaction to Humans, Zh. Vyssh. Nervn. Deyat., 1985, vol. 35, pp. 142–146.

    Google Scholar 

  23. Malmkvist, J., Hansen, S.W., and Damgaard, B.M., Effect of the Serotonin Agonist Buspirone on Behavior and Hypothalamic-Pituitary-Adrenal Axis in Confident and Fearful Mink, Physiol. Behav., 2003, vol. 78, pp. 229–240.

    Article  PubMed  Google Scholar 

  24. Weiner, R.J., Findel, P.R., and Kordon, C., Role of Classic and Peptide Neurotransmitters in the Neuroendocrine Regulation of LH and Prolactin, The Physiology of Reproduction, New York, Raven, 1988, pp. 1235–1281.

  25. Trapezov, O.V., Kharlamova, A.V., and Shulga, V.A., Glucocorticoids and White Spottiness in Minks, Krolikovod. Zverovod., 1997, no. 3, pp. 14–15.

Download references

Author information

Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    D. V. Klochkov, T. A. Alekhina, O. V. Trapezov & O. I. Petrenko

Authors
  1. D. V. Klochkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. A. Alekhina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. V. Trapezov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. O. I. Petrenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, Vol. 41, No. 3, 2005, pp. 266–271.

Original Russian Text Copyright © 2005 by Klochkov, Alekhina, Trapezov, Petrenko.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Klochkov, D.V., Alekhina, T.A., Trapezov, O.V. et al. Estrous Cycle, Folliculogenesis, and Brain Catecholamines after Stimulation of the Sexual System by Choriogonadotropin in Female Minks Selected for Behavior. J Evol Biochem Phys 41, 333–340 (2005). https://doi.org/10.1007/s10893-005-0067-6

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10893-005-0067-6

Keywords

Search

Navigation