Abstract
Electrophysiological changes in the wakefulness—sleep cycle were studied in early postnatal ontogenesis of rat pups. EEG was recorded and its spectral power was determined, as well as spatial-temporal synchronization between the brain cortex zones (visual and sensomotor) and hippocampus in the process of sleep at various periods of ontogenesis. These data were compared with the literature data on studying of cytoarchitectonics and ultrastructure of rat neocortex as well as on formation of neuronal activity and maturation of transmitter systems at the same periods. Based on time of formation of interneuronal and interstructural connections and of maturation of transmitter systems, 3 stages of functional development of sleep in ontogenesis were identified: the first stage—undifferentiated sleep, the interneuronal connections are absent; the second stage—partially differentiated sleep, interneuronal connections function and control from subcortical structures appears; the third stage—differentiated sleep, clear division into sleep phase, additional control from all three transmitter systems: noradrenergic, cholinergic, and serotoninergic, action of the latter providing inhibitory mechanisms in CNS.
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Translated from Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, Vol. 41, No. 2, 2005, pp. 154–159.
Original Russian Text Copyright © 2005 by Titkov, Aristakesyan, Oganesyan.
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Titkov, E.S., Aristakesyan, E.A. & Oganesyan, G.A. Peculiarities of Formation of the Wakefulness—Sleep Cycle in Ontogenesis of Rats. J Evol Biochem Phys 41, 194–200 (2005). https://doi.org/10.1007/s10893-005-0054-y
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DOI: https://doi.org/10.1007/s10893-005-0054-y