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Effects of total sleep deprivation in rats with hereditary predisposition to audiogenic convulsions

  • Comparative and Ontogenic Physiology
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Abstract

In rats of the Krushinskii-Molodkina (KM) line with hereditary predisposition to audiogenic convulsions there were studied effects of total sleep deprivation for 3, 6, and 9 h by a light arousal or a slow rotation in a roller on spectral EEG characteristics in the wakefulness-sleep cycle, organization of the cycle, and intensity of convulsive symptoms at the recovery period. The data are presented on dynamics of recovery of the cycle structure for 12 h of postdeprivation period. It has been established that during and after the total sleep deprivations of any duration no paroxysmal discharges appear in EEG of hippocampus, caudate nucleus, medial central thalamic nucleus, somatosensory, visual, and auditory cerebral cortex in any of states of the wakefulness-sleep cycle. These deprivations were also shown to have no effect on the latent period value and parameters of generalized tonic-clonal audiogenic convulsions. At the same time, after 6 and 9 h of the total sleep deprivations in a slowly rotating roller there was revealed in some animals a change of the type of response to the sound stimulus. Such decrease of reaction of rats to audiogenic stimuli seems to be due to alertness of the animals. It is stated that in the KM rats, with the hidden convulsive syndrome, we failed to activate epileptiform manifestations by the used types and ways of the total sleep deprivations.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    S. I. Vataev & G. A. Oganesyan

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  1. S. I. Vataev
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  2. G. A. Oganesyan
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Translated from Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, Vol. 41, No. 1, 2005, pp. 82–88.

Original Russian Text Copyright © 2005 by Vataev, Oganesyan.

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Vataev, S.I., Oganesyan, G.A. Effects of total sleep deprivation in rats with hereditary predisposition to audiogenic convulsions. J Evol Biochem Phys 41, 103–111 (2005). https://doi.org/10.1007/s10893-005-0041-3

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  • DOI: https://doi.org/10.1007/s10893-005-0041-3

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