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Analysis of rheograms of the blood of patients with myocardial ischemia and type-2 diabetes mellitus with the use of a new model in the process of pharmaceutical therapy

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Abstract

Curves of the blood flow in patents with myocardial ischemia (MI), patients with MI and type-2 diabetes mellitus (MI + DM2), and donors have been analyzed using a rheological model proposed by the authors. The influence of the standard antianginal and antiaggregative therapy on the parameters of this model has been investigated. It has been established that the four parameters of the model are reliably changed for both groups of patients as compared to those for the healthy donors, and that, for the donors, there exists a temperature-dependent correlation between the other two parameters of the model that is absent for the patients. A criterion is proposed for estimating a normal blood-flow curve at 25°C. It is shown that the antianginal and antiaggregative therapies do not influence the parameters of the model for the patients studied.

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References

  1. T. Cicha, Y. Suzuki, N. Tateishi, and N. Maeda, Enhancement of red blood cell aggregation by plasma triglycerides, Clin. Hemorheol. Microcirc., 24, No. 4, 247–255 (2001).

    Google Scholar 

  2. V. E. Formazyuk and G. E. Dobretsov, Microviscosity of lipoproteins of blood plasma and risk of myocardial ischemia, Biofizika, 26, Issue 2, 534–535 (1981).

    Google Scholar 

  3. A. Haas, M. Walzl, F. Jesenik, B. Walzl, A. Berghold, J. Bergloff, B. Feigl, and J. Faulborn, Application of HELP in nonarteritic anterior ischemic optic neuropathy: A prospective, randomized, controlled study, Graefes Arch. Clin. Exp. Ophthalmol., 235, No. 1, 14–19 (1997).

    Article  Google Scholar 

  4. R. Koppensteiner, A. Moritz, R. Moidl, M. Banyai, M. Haumer, E. Wolner, and H. Ehringer, Blood rheology in patients with native heart valve disease and after valve replacement, Am. J. Cardiol., 81, No. 2, 250–252 (1998).

    Article  Google Scholar 

  5. C. Le Devehat, Blood rheology abnormalities in diabetes mellitus, J. Mal. Vasc., 14, No. 1, 64–67 (1989).

    Google Scholar 

  6. P. Poredos and B. Zizek, Plasma viscosity increase with progression of peripheral arterial atherosclerotic disease, Angiology, 47, No. 3, 253–259 (1996).

    Google Scholar 

  7. E. Rillaerts, L. van Gaal, D. Z. Xiang, G. Vansant, and I. De Leeuw, Blood viscosity in human obesity: Relation to glucose tolerance and insulin status, Int. J. Obes., 13, No. 6, 739–745 (1989).

    Google Scholar 

  8. M. E. Rogers, D. T. Williams, R. Niththyananthan, M. W. Rampling, K. E. Heslop, and D. G. Johnston, Decrease in erythrocyte glycophorin sialic acid content as associated with increased erythrocyte aggregation in human diabetes, Clin. Sci. (Colch.), 82, No. 3, 309–313 (1992).

    Google Scholar 

  9. R. S. Rosenson, A. McCormick and E. F. Uretz, Distribution of blood viscosity values and biochemical correlates in healthy adults, Clin. Chem., 42, No. 8, Pt. 1, 1189–1195 (1996).

    Google Scholar 

  10. E. Schutz, P. Schuff-Werner, Y. Guttner, S. Schulz, and V. W. Armstrong, Investigations into the haemorheological significance of postprandial and fasting hypertriglyceridaemia, Eur. J. Clin. Invest., 23, No. 5, 270–276 (1993).

    Google Scholar 

  11. V. Turchetti, F. Leoncini, C. De Matteis, L. Trabalzini, M. Guerrini, and S. Forconi, Evaluation of erythrocyte morphology as deformability index in patients suffering from vascular diseases, with or without diabetes mellitus: Correlation with blood viscosity and intra-erythrocytic calcium, Clin. Hemorheol. Microcirc., 18, Nos. 2–3, 141–149 (1998).

    Google Scholar 

  12. Z. P. Shul’man and I. V. Yamaikina, Dependence of the viscosity on the concentration of particles with the example of blood and erythrocytic suspensions, Inzh.-Fiz. Zh., 76, No. 3, 165–168 (2003).

    Google Scholar 

  13. I. V. Yamaikina, Z. P. Shul’man, L. I. Ershova, Z. M. Likhovetskaya, and N. A. Gorbunova, New rheological model for analyzing the aggregation and deformation ability of erythrocytes in the case of hematological pathologies, Inzh.-Fiz. Zh., 77, No. 2, 130–133 (2004).

    Google Scholar 

  14. I. V. Yamaikina and Z. P. Shul’man, Relation between the parameters of a rheological model and the geometric characteristics of particles, in: Heat and Mass Transfer-2003 [in Russian], Collection of Papers of the Heat and Mass Transfer Institute, National Academy of Sciences of Belarus, Minsk (2003), pp. 125–128.

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Authors and Affiliations

  1. A. V. Luikov Heat and Mass Transfer Institute, National Academy of Sciences of Belarus, 15 P. Brovka Str., Minsk, 220072, Belarus

    I. V. Yamaikina

  2. Belarusian State Medical University, 83 Dzerzhinskii Ave., Minsk, 220116, Belarus

    G. Kh. Tagkhizadekh & N. P. Mit’kovskaya

Authors
  1. I. V. Yamaikina
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  2. G. Kh. Tagkhizadekh
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  3. N. P. Mit’kovskaya
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Translated from Inzhenerno-Fizicheskii Zhurnal, Vol. 78, No. 5, pp. 186–189, September–October, 2005.

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Yamaikina, I.V., Tagkhizadekh, G.K. & Mit’kovskaya, N.P. Analysis of rheograms of the blood of patients with myocardial ischemia and type-2 diabetes mellitus with the use of a new model in the process of pharmaceutical therapy. J Eng Phys Thermophys 78, 1029–1033 (2005). https://doi.org/10.1007/s10891-006-0031-3

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  • DOI: https://doi.org/10.1007/s10891-006-0031-3

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