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Nematicidal Resorcylides from the Aquatic Fungus Caryospora callicarpa YMF1.01026

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Abstract

This study investigated metabolites with activities against plant parasite nematodes from the fresh-water fungus Caryospora callicarpa YMF1.01026. We obtained three novel tetradecalactone metabolites, caryospomycins A–C, with such activities. The chemical structures of these were determined through NMR spectroscopic analysis and were found to belong to the 14-membered macrolides with a fused 1,2-dimethoxy-4-hydroxybenzene ring, a rare structure among the resorcylides. In the in vitro tests, all three compounds exhibited moderate killing activity against the nematode Bursaphelenchus xylophilus. To our knowledge, this is the first report of secondary metabolites in the aquatic fungal genus Caryospora.

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Acknowledgements

This study was financially supported by the National Natural Science Foundation of China (NSFC30570059 and NSFC20562015), Yunnan Provincial Natural Science Foundation (2005C0005Q, 2005NG03 and 2005NG05), and the State Key Laboratory of Phytochemistry and Plant Resources in Western China, Kunming Institute of Botany, China. We are grateful to Dr. L. Cai for providing strain Caryospora carllicarpa YMF1.01026.

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Authors and Affiliations

  1. Key Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming, Yunnan, 650091, People’s Republic of China

    Jinyan Dong, Yanhui Zhu, Ru Li, Rong Huang, Yongping Zhou, Le Wang, Yi Cao & Keqin Zhang

  2. Provincial Key Laboratory of Rural Energy Engineering, Yunnan Normal University, Kunming, 650092, People’s Republic of China

    Hongchuan Song

  3. Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650204, People’s Republic of China

    Hongping He & Haiyang Liu

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  1. Jinyan Dong
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  2. Yanhui Zhu
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  3. Hongchuan Song
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Correspondence to Keqin Zhang.

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Dong, J., Zhu, Y., Song, H. et al. Nematicidal Resorcylides from the Aquatic Fungus Caryospora callicarpa YMF1.01026. J Chem Ecol 33, 1115–1126 (2007). https://doi.org/10.1007/s10886-007-9256-7

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