To evaluate the bias and precision of the respiratory muscle training device formulas to predict respiratory minute volume (RMV) and volume of the reservoir bag (BV) on a cohort of subjects with Cystic Fibrosis (CF). CF patients with available pulmonary function tests and maximal voluntary manoeuvres were included in the study. Vital capacity and maximal voluntary ventilation were extracted from subjects’ records and then inserted to the manufacturer’s formulas to obtain RMV and BV (measured setting). RMV and BV were compared according to standard and measured formulas in males and females. Sample was described and then processed using Bland–Altman analysis. Bland–Altman analysis for RMV revealed a bias and precision of 8.8 ± 29 L/min in males and 28.8 ± 16 L/min in females; 0.4 ± 0.5 L in males and 0.7 ± 0.4 L in females for BV. Concordance correlation coefficients for RMV were −0.03 in males and 0.02 in females; 0.22 in males and 0.03 in females for BV, reinforcing an unsatisfactory concordance between measured and manufacturer setting. This study shows considerable discrepancies between the two methods, making the degree of agreement not clinically acceptable. This might cause inappropriate setting and disservice to patients with CF.
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Conflict of interest
The authors have no conflict of interest to declare. The authors have not received any financial support for the preparation of this manuscript. No commercial party having a direct financial interest in the results of the research supporting this article has conferred or will confer a benefit on the authors or on any organization with which the authors are associated.
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Gambazza, S., Ceruti, C., Brivio, A. et al. Isocapnic hyperpnea with a portable device in Cystic Fibrosis: an agreement study between two different set-up modalities. J Clin Monit Comput 29, 569–572 (2015). https://doi.org/10.1007/s10877-014-9633-z
- Cystic Fibrosis
- Respiratory muscle training