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The Initial Tangent of the Aortic Pressure Increase is an Estimate of Left Ventricular Contractility in Pigs

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Abstract

The aim was, to identify an estimate of left ventricular contractility derived from the aortic pressure wave without load changing manoeuvres. For this purpose, left ventricular contractility was assessed with several aortic pressure wave form derived parameters and was compared to standard parameters of left ventricular contractility (conductance technique) in an experimental study. Measurements were taken during baseline, after β-stimulation and after injection of a β-antagonist. The initial and the secondary tangent, the area under the aortic pressure, and the stroke volume were correlated with the endsystolic elastance, a mainly load independent measure of left ventricular contractility: The initial tangent of the aortic pressure increase correlated significantly with the endsystolic elastance (r = 0.54, P < 0.05). The initial tangent of the aortic pressure increase was significantly increased from baseline at β-stimulation (from 20.2 ± 4.7 to 36.4 ± 6.8 mmHg  s−1, P < 0.05) and decreased after injection of a β-antagonist (from 20.2 ± 4.7 to 12.3 ± 2.0, P < 0.05). Thus, we conclude that the initial tangent of the aortic pressure increase is a valid estimate of left ventricular contractility in piglets.

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Acknowledgements

The excellent research terms as provided by Prof. Dr. Med. Dr. H. C. Mult. Konrad Messmer are greatly acknowledged. Brigitte Blount (nationally certified keeper) and her team for professional animal care. The study was supported by a research grant (Reg-No.: 79) of the Ludwig Maximilian University of Munich.

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Authors and Affiliations

  1. Clinic of Anesthesiology, Ludwig Maximilian University, Marchioninistr. 15 and 27, 81377, Munich, Germany

    Hille Kisch-Wedel MD, Michael Flondor MD & Bernhard Zwissler MD

  2. Institute For Surgical Research, Ludwig Maximilian University, Marchioninistr. 15 and 27, 81377, Munich, Germany

    Hille Kisch-Wedel MD, Gregor Kemming MD, PhD, Franz Meisner MD, Michael Flondor MD, Sebastian Bruhn & Carolina Koehler MD

  3. Clinic for Anesthesiology, Günzburg, Germany

    Gregor Kemming MD, PhD

  4. Department of Thoracic and Vascular Surgery, Surgical Clinic, University of Ulm, Ulm, Germany

    Franz Meisner MD

Authors
  1. Hille Kisch-Wedel MD
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  2. Gregor Kemming MD, PhD
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  3. Franz Meisner MD
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  4. Michael Flondor MD
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  5. Sebastian Bruhn
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  6. Carolina Koehler MD
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  7. Bernhard Zwissler MD
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Corresponding author

Correspondence to Hille Kisch-Wedel MD.

Additional information

Kisch-Wedel H, Kemming G, Meisner F, Flondor M, Bruhn S, Koehler C, Zwissler B. The initial tangent of the aortic pressure increase is an estimate of left ventricular contractility in pigs.

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Kisch-Wedel, H., Kemming, G., Meisner, F. et al. The Initial Tangent of the Aortic Pressure Increase is an Estimate of Left Ventricular Contractility in Pigs. J Clin Monit Comput 22, 375–380 (2008). https://doi.org/10.1007/s10877-008-9145-9

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  • DOI: https://doi.org/10.1007/s10877-008-9145-9

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