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Manganese Iron Oxide Nanoparticles for Magnetic Hyperthermia, Antibacterial and ROS Generation Performance

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Abstract

The preparation of manganese substituted iron oxide magnetic nanoparticles by polyol synthesis route. Due to the unique properties, diethylene glycol (DEG) and tri-ethylene glycol (TEG) used as a solvent in synthesis method with different volumetric variations. The structural, morphological and hyperthermic properties of prepared samples are investigated. Formation of single-phase cubic spinel lattice for all compositions confirmed by X-ray diffraction and crystallite size was found to be decreased from 20.6 ± 1.3 to 15.2 ± 1.7 nm with varying ratio of DEG/TEG. Transmission electron microscopy (TEM) analysis displayed spherical grains with an agglomeration of the MnFe2O4 magnetic nanoparticles (MNPs). Heating ability of MNPs studied with an induction heating system under different magnetic field strengths at 20 kA/m and 26.6 kA/m by varying nanoparticle concentrations at fixed frequency of 278 kHz. Antimicrobial activity on E. coli and antifungal activity on C. albicans showed effectiveness of MNPs at 10 mg/mL for such activities. Additionally, ROS induction in presence of MNPs illustrates probable action against E. coli and C. albicans and as antibacterial and antifungal agent in the medical field due to ROS generation ability.It has been shown that these optimized MNPs will play multifaceted roles for magnetic hyperthermia therapy as heat mediators, and antibacterial/antifungal agents owing to their magnetic induction heating properties and biological activities.

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Funding

Author Vishwajeet M. Khot thankful to the D. Y. Patil Education Society (Deemed to be University), Kolhapur for financial support through the research project (sanction no. DYPES/DU/R&D/2021/276). Author Sagar A. Patil gratefully thank to Chhatrapati Shahu Maharaj Research Training and Human Development Institute (SARTHI), Government of Maharashtra, India, for awarding the CSMNRF-2022 Research Fellowship. Author Ashwini. B. Salunkhe acknowledge the financial support from UGC-DAE CSR through a collaborative research scheme (CRS) project number CRS/2021–2022/01/444.

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Authors and Affiliations

  1. Department of Medical Physics, Centre for Interdisciplinary Research, D. Y. Patil Education Society (Deemed to be University), Kolhapur, Maharashtra, 416006, India

    Sagar A. Patil, Maithili V. Londhe & Vishwajeet M. Khot

  2. Department of Stem Cell and Regenerative Medicine, Centre for Interdisciplinary Research, D. Y. Patil Education Society (Deemed to be University), Kolhapur, Maharashtra, 416006, India

    Tanjila C. Gavandi & Ashwini K. Jadhav

  3. Department of Physics, Rajaram College, Kolhapur, Maharashtra, 416003, India

    Maithili V. Londhe & Ashwini B. Salunkhe

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  1. Sagar A. Patil
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  2. Tanjila C. Gavandi
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  3. Maithili V. Londhe
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  4. Ashwini B. Salunkhe
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  5. Ashwini K. Jadhav
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Sagar A. Patil, Tanjila C. Gavandi, Maithili V. Londhe, Ashwini B. Salunkhe, Ashwini K. Jadhav and Vishwajeet M. Khot. The first draft of the manuscript was written by Sagar A. Patil and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Vishwajeet M. Khot.

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Patil, S.A., Gavandi, T.C., Londhe, M.V. et al. Manganese Iron Oxide Nanoparticles for Magnetic Hyperthermia, Antibacterial and ROS Generation Performance. J Clust Sci (2024). https://doi.org/10.1007/s10876-024-02598-w

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