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Design, Synthesis, Characterization, Anti-Microbial, Anti-Oxidant, DNA, HSA, Cytotoxicity and Anti-Inflammatory Studies of Nitrogen-Substituted Chrysin Derivatives and Metal(II) Complexes

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Abstract

A novel chrysin derivatives of ligand has been synthesized by the condensation of n-pentyl amine, pyrrole and substituent 3-aminonaphthalene-2-ol and its Co(II), Ni(II), Cu(II) and Zn(II) complexes have been reported. The ligands and its metal complexes have been structurally characterized using a variety of spectroscopic [UV–Vis, IR, NMR, ESR, Mass, XPRD], thermal (TGA) and other physicochemical techniques. For in vitro antibacterial activity, all the produced compounds have been evaluated. Additionally, the compounds have been used in antioxidant investigations. UV–Vis spectroscopy, Fluorescence quenching and viscosity measurements techniques were used to examine the binding affinity of complexes with DNA and Human Serum Albumin (HSA). As a result of the gathered data, it was discovered that DNA and HSA had a preference for the following complexes: Cu-L > Zn-L > Co-L > Ni-L and Ni-L > Cu-L > Zn-L > Co-L. The complexes were further tested for their in vitro anticancer activity against the cell lines (HeLa & MCF-7) and the findings obtained suggest that they demonstrate an effective anticancer activity. The metal complexes performed various biochemical assay techniques for anti-inflammatory and anti-tubercular studies.

Graphical Abstract

A series of chrysin derivatives of ligand and their corresponding metal(II) complexes of general formula: [M-L(OAc)] were synthesized and characterized using spectroscopic techniques. The hetero-bimetalic complexes show moderate biological activity and catalyst precursors.

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Acknowledgements

I thank Department of Pharmaceutical Chemistry Manonmaniam Sundaranar University & Department of Chemistry, Manonmaniam Sundaranar University, for the support to carry out this work.

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  1. Department of Pharmaceutical Chemistry, Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, 627012, India

    Ebenezer Bonpandi

  2. Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, 627012, India

    Nagashri Kandasamy

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Bonpandi, E., Kandasamy, N. Design, Synthesis, Characterization, Anti-Microbial, Anti-Oxidant, DNA, HSA, Cytotoxicity and Anti-Inflammatory Studies of Nitrogen-Substituted Chrysin Derivatives and Metal(II) Complexes. J Clust Sci 34, 2113–2134 (2023). https://doi.org/10.1007/s10876-022-02372-w

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