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RETRACTED ARTICLE: Treatment Activity of a New Pr(III) Coordination Polymer on Diabetic Retinopathy by Regulating miR-107/HMGB1 in Retinal Vascular Cells

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This article was retracted on 30 January 2024

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Abstract

A lanthanide coordination polymer (Ln-CP), {Pr2(PBA)3(H2O)3]·DMF·3H2O}n (1), was synthesized using 5-(4-pyridin-3-yl-benzoylamino)-isophthalic acid (H2PBA), a tripodal carboxylic ligand. Moreover, the relative expression of miR-107 was evaluated through RT-PCR. miR-107 effect was then detected with the CCK-8 assay. ROS detection and ELISA were used to assess the inflammatory response in retinal vascular cells. miR-107 downstream regulation was also investigated. TargetScan was applied to predict the latent proteins that bind to miR-107 via the 3′-UTR, which was demonstrated in-depth through luciferase activity assay. All outcomes indicated that the miR-107 level was lower in retinal vascular cells in a diabetic retinopathy (DR) model. miR-107 expression could further regulate the proliferation of retinal vascular cells and inhibit inflammation, thereby playing a protective role in the function of retinal vascular cells. Thus, miR-107 may be an upstream regulatory factor of high-mobility group box 1, and let 7-5p may be a latent molecular target to treat DR.

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Acknowledgements

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Funding

The research was funded by Natural Science Foundation of Shandong Province (ZR2015HL112) and Science and Technology Development Plan of Tai’an City (2017NS0171).

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Authors and Affiliations

  1. Department of Ophthalmology, Qingdao Hospital of Traditional Chinese Medicine (Qingdao Hiser Hospital), Qingdao, Shandong, China

    Fei-Fei Yu

  2. Department of Ophthalmology, Tai’an City Central Hospital, Tai’an, Shandong, China

    Yun-Hong Du & Guo-Long Pang

  3. Postdoctoral Mobile Station of Shandong University, Tai’an, Shandong, China

    Guo-Long Pang

Authors
  1. Fei-Fei Yu
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  2. Yun-Hong Du
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Correspondence to Yun-Hong Du or Guo-Long Pang.

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This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1007/s10876-024-02573-5

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Yu, FF., Du, YH. & Pang, GL. RETRACTED ARTICLE: Treatment Activity of a New Pr(III) Coordination Polymer on Diabetic Retinopathy by Regulating miR-107/HMGB1 in Retinal Vascular Cells. J Clust Sci 34, 1185–1194 (2023). https://doi.org/10.1007/s10876-021-02200-7

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  • DOI: https://doi.org/10.1007/s10876-021-02200-7

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