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Synergic Fabrication of Gold Nanoparticles Embedded Dextran/ Silk Sericin Nanomaterials for the Treatment and Care of Wound Healing

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Abstract

Gold-loaded nanoparticles are versatile nanomaterials that may be used in wound healing properties. The current study describes a wound dressing formulation focused on Gold-loaded Dextran/Silk Sericin nanoparticles. The Gold-loaded Dextran/Silk Sericin membranes were fabricated using Gold solutions inside the Dextran/Silk Sericin medium. The influence of various experimental conditions on Dextran/Silk Sericin nanoparticle formations were examined. The sizes of Dextran/Silk Sericin and Gold@Dextran/Silk Sericin nanoparticles were examined through the HR-SEM. Moreover, the efficacy antibacterial activity of Dextran/Silk Sericin and Gold-loaded Dextran/Silk Sericin nanoparticles was evaluated against the microorganisms gram-positive and negative. Furthermore, we observed the in vivo wound healing of wounds in skin using a mice model over a 16 days period. In this difference to the wounds of untreated mouse, quick healing was observed in the Gold-loaded Dextran/Silk Sericin nanoparticles-treated wounds with fewer injury. These results specify that Gold-loaded Dextran/Silk Sericin nanoparticles-based dressing material could be a ground-breaking nanomaterial having wound repair and implantations potential required for wound damages, which was proven using an animal model.

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  1. Operating Room, The First People’s Hospital of Lianyungang & Xuzhou Medical University Affiliated to Hospital of Lianyungang, NO. 182 Tongguan North Road, Lianyungang, 222000, Jiangsu, China

    Ping Chen, Leina Bian & Xiaoyan Hu

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Chen, P., Bian, L. & Hu, X. Synergic Fabrication of Gold Nanoparticles Embedded Dextran/ Silk Sericin Nanomaterials for the Treatment and Care of Wound Healing. J Clust Sci 33, 2147–2156 (2022). https://doi.org/10.1007/s10876-021-02131-3

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