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Improved Primary Lung Carcinoma Therapeutics Utilizing a Non-Invasive Approach of Combinatorial Drug Loaded Aerosolized Dry Inhaler Powder

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Abstract

Lung cancer has become an immediate concern and reviewing the side effects associated with conventional chemotherapy, with the advent of nanobiomedicine, various nanoformulations are being researched. In the current study, our team has investigated aerosolized dry inhaler powder loaded with a combination of two potent anti-cancer drugs, cisplatin and paclitaxel for locoregional delivery of the same to the lung tissues. This nanoformulation has been investigated by morphological analysis and in-vitro studies to ensure proper therapeutics. Its efficacy has been determined by the anti-tumor studies. The size of the DPIs have been found to be in the range of 60–85 nm small enough to escape the clearance mechanisms in the pulmonary route. The nanoformulations with size < 200 nm easily move to the tumor vasculature which has been exploited completely here. The fine particle fraction (< 5 µm) deposited in the lungs was found to be 50%. They were also associated with reduced toxicity and they efficiently reduced the tumor volume by 75%. Therefore we may safely conclude that the current formulation overcomes the striking hindrances of nanocomposites namely increased toxicity, higher clearance from system and low efficacy due to inefficient targeting of drug.

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Authors and Affiliations

  1. Department of Pharmacy, Tianjin Beichen District Chinese Medicine Hospital, Tianjin, 300400, China

    Lianrui Li, Jun Yu & Zhiyong Chen

  2. Clinical Pharmacy Office, Pharmacy School of Tianjin Medical University, Tianjin, 300070, China

    Jun Zhang

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  1. Lianrui Li
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  2. Jun Yu
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Contributions

Conceptualization: JZ; Methodology: JZ, LL, JY, ZC; Formal analysis and Investigation: LL, JY, ZC; Writing (Original draft preparation) LL; JZ Writing—review & editing: JZ. The manuscript has been read and approved by all the authors, that the requirements for authorship as stated earlier in this document have been met, and that each author believes that the manuscript represents honest work.

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Correspondence to Jun Zhang.

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The authors declare no conflicts of interests.

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The institutional small animal ethics committee had approved the study vide ethical approval nr. 56–2-10/2018. All animal studies have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Li, L., Yu, J., Chen, Z. et al. Improved Primary Lung Carcinoma Therapeutics Utilizing a Non-Invasive Approach of Combinatorial Drug Loaded Aerosolized Dry Inhaler Powder. J Clust Sci 33, 1781–1791 (2022). https://doi.org/10.1007/s10876-021-02103-7

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  • DOI: https://doi.org/10.1007/s10876-021-02103-7

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