Influence of Morphology and Textural Characteristics of γ-Al2O3 Nanostructures on the Potentiation of Doxorubicin

Abstract

The combined application of chemotherapeutic agents and nanoparticles is a universal strategy in malignant tumors treatment. In the present study influence of γ-Al2O3 nanostructures morphology on its ability to potentiate doxorubicin was evaluated. Combined application of nanostructures and doxorubicin was evaluated using Neuro-2a, Hela, MCF-7 cell lines. It was found that regardless of γ-Al2O3 nanostructures morphology, its combined application with doxorubicin lead to synergetic effect. Moreover, the synergetic effect is observed at concentrations lower than IC50 values for monotherapy.

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Acknowledgements

The work was performed according to the Government research assignment for ISPMS SB RAS, Project No. III. 23.2.10.

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Correspondence to Alla Fomenko.

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Fomenko, A., Kazantsev, S., Lozhkomoev, A.S. et al. Influence of Morphology and Textural Characteristics of γ-Al2O3 Nanostructures on the Potentiation of Doxorubicin. J Clust Sci (2021). https://doi.org/10.1007/s10876-021-02009-4

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Keywords

  • Nanoparticles
  • γ-Al2O3
  • Synergistic drug combinations
  • Cancer therapy