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Influence of Morphology and Textural Characteristics of γ-Al2O3 Nanostructures on the Potentiation of Doxorubicin

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Abstract

The combined application of chemotherapeutic agents and nanoparticles is a universal strategy in malignant tumors treatment. In the present study influence of γ-Al2O3 nanostructures morphology on its ability to potentiate doxorubicin was evaluated. Combined application of nanostructures and doxorubicin was evaluated using Neuro-2a, Hela, MCF-7 cell lines. It was found that regardless of γ-Al2O3 nanostructures morphology, its combined application with doxorubicin lead to synergetic effect. Moreover, the synergetic effect is observed at concentrations lower than IC50 values for monotherapy.

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Acknowledgements

The work was performed according to the Government research assignment for ISPMS SB RAS, Project No. III. 23.2.10.

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Authors and Affiliations

  1. Institute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of Sciences (ISPMS SB RAS), Tomsk, Russia

    Alla Fomenko, Sergey Kazantsev, A. S. Lozhkomoev, N. G. Rodkevich & A. A. Miller

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  1. Alla Fomenko
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  2. Sergey Kazantsev
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  3. A. S. Lozhkomoev
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  4. N. G. Rodkevich
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  5. A. A. Miller
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Correspondence to Alla Fomenko.

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Fomenko, A., Kazantsev, S., Lozhkomoev, A.S. et al. Influence of Morphology and Textural Characteristics of γ-Al2O3 Nanostructures on the Potentiation of Doxorubicin. J Clust Sci 33, 949–955 (2022). https://doi.org/10.1007/s10876-021-02009-4

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