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Synthesis of Superparamagnetic Zinc Ferrite Encased Fluorapatite Nanoparticles and Its Cytotoxicity Effects on MG-63 Cells

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Abstract

Zinc ferrite (ZnFe2O4) nanoparticles encased fluorapatite (FAP) nanorods was successfully synthesized through hydrothermal method for biomedical applications. TEM image revealed the formation of ZnFe2O4 nanoparticle encased FAP nanorods with average size of about 60 ± 40 nm. Both ZnFe2O4 and ZnFe2O4–FAP samples exhibited superparamagnetic nature at 300 K with saturation magnetization (Ms) of 28.41 and 4.13 emu/g, respectively. Further, the superparamagnetic property of the ZnFe2O4 was investigated using langevin function and average magnetic moment per particle was found to be 606 \({\mu }_{B}\). ZnFe2O4–FAP nanorods exhibited enhanced colloidal stability when compared to ZnFe2O4 nanospheres. The cytotoxicity results confirmed the enhanced cell viability (86%) at 500 µg/mL of ZnFe2O4–FAP nanorods than that of ZnFe2O4 nanospheres (76%). The above results indicate that the ZnFe2O4–FAP nanorods can be considered as a potential candidate for biomedical applications.

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Acknowledgements

The authors (GAK and DKS) express their sincere thanks to National Science Foundation Partnerships for Research and Education in Materials (NSF-PREM) grant NO-DMR-0934218 for financial support. K. Matrisoyan expresses their sincere thanks to NSF PREM (award DMR 1523577: UTRGV UMN Partnership for Fostering Innovation by Bridging Excellence in Research and Student Success) for financial support.

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Authors and Affiliations

  1. Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 47504, People’s Republic of China

    S. Karthi

  2. Department of Physics, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore, 641020, Tamil Nadu, India

    P. Vivek

  3. Department of Physics, Periyar University, Salem, 636011, Tamil Nadu, India

    D. Karthickraja & E. K. Girija

  4. Department of Physics and Astronomy, University of Texas at San Antonio, San Antonio, TX, 78249, USA

    G. A. Kumar & D. K. Sardar

  5. Department of Atomic and Molecular Physics, Manipal University, Manipal, 576104, Karnataka, India

    G. A. Kumar

  6. Department of Natural Sciences, Texas Agriculture and Mechanical University, One University Way, San Antonio, TX, 78224, USA

    G. A. Kumar

  7. Department of Physics and Astronomy, University of Texas at Rio Grande Valley, Brownsville, TX, 78520, USA

    C. Dannangoda & K. S. Martirosyan

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  1. S. Karthi
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  2. P. Vivek
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  8. E. K. Girija
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Correspondence to E. K. Girija.

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Dr. S. Karthi deceased on 7th August 2020.

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Karthi, S., Vivek, P., Karthickraja, D. et al. Synthesis of Superparamagnetic Zinc Ferrite Encased Fluorapatite Nanoparticles and Its Cytotoxicity Effects on MG-63 Cells. J Clust Sci 33, 261–267 (2022). https://doi.org/10.1007/s10876-020-01946-w

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  • DOI: https://doi.org/10.1007/s10876-020-01946-w

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