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Core–Shell Structured NaYF4:Yb,Er Nanoparticles with Excellent Upconversion Luminescent for Targeted Drug Delivery

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Abstract

A core–shell-structured composite by combining mesoporous silica with upconversion luminescence (UCL) property had considerable application potentials in the fields of drug delivery, disease diagnosis, and therapy. In this paper, a monodisperse, core–shell-structured NaYF4:Yb,Er@nSiO2@mSiO2 nanoparticle (UCNP@MSNs-FA) with excellent UCL property was successfully fabricated by a facile two-step sol–gel strategy and by modifying the surface with folic acid (FA) to strengthen its tumor-targeting performance. The properties of the composite were studied extensively, which indicated that UCNP@MSNs-FA possessed good dispersion, typical core–shell-structured with high specific surface area (132.775 m2/g), and excellent UCL property that improve cell imaging and drug delivery. The viability of L929 cells and hemolysis assay demonstrated the good biocompatibility of the composite. By using doxorubicin hydrochloride (DOX) as a model drug, the drug loading content and encapsulation efficiency of UCNP@MSNs-FA could reach as high as 11.2% and 37.3%, respectively, which proved the effectiveness to load anticancer drugs. In addition, the DOX-UCNP@MSNs-FA system exhibited sustained drug release and strong pH-dependent performance, in which the drug release would be accelerated at the slightly acidic microenvironment in the tumor. Moreover, experimental results indicated that DOX-UCNP@MSNs-FA exhibited specific cytotoxicity to KB cells but weakened toxicity to FR-negative cells. Therefore, the as-prepared UCNP@MSNs-FA could be used potential for simultaneous targeted anti-cancer drug delivery and cell imaging and enhance the therapeutic efficacy against FR-positive tumor cells.

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Acknowledgements

Project supported by the Key Research and Development Plan of Shaanxi Province (2020GY-313), the Specialized Research Fund of Education Department of Shaanxi Province (19JK0255), the Specialized Scientific Research Fund Projects of Academician Shengyong Zhang (18YSZX001), and the Science and Technology Innovation Team of Shangluo (SK2017-45)

Funding

Project supported by the Key Research and Development Plan of Shaanxi Province (2020GY-313), the Specialized Research Fund of Education Department of Shaanxi Province (19JK0255), the Specialized Scientific Research Fund Projects of Academician Shengyong Zhang (18YSZX001), and the Science and Technology Innovation Team of Shangluo (SK2017-45).

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Authors and Affiliations

  1. College of Biology Pharmacy and Food Engineering, Shangluo University, No. 10 Beixin Street, Shangluo, 726000, People’s Republic of China

    Xuhua Liang & Yanyan Zhao

  2. Shaanxi Qinling Industrial Technology Research Institute of Special Biological Resources, Shangluo, People’s Republic of China

    Xuhua Liang

  3. College of Food Science and Technology, Northwest University, Xi’an, People’s Republic of China

    Jun Fan & Yanyan Zhao

  4. College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, People’s Republic of China

    Ruyi Jin

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  1. Xuhua Liang
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Correspondence to Xuhua Liang.

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Liang, X., Fan, J., Zhao, Y. et al. Core–Shell Structured NaYF4:Yb,Er Nanoparticles with Excellent Upconversion Luminescent for Targeted Drug Delivery. J Clust Sci 32, 1683–1691 (2021). https://doi.org/10.1007/s10876-020-01929-x

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  • DOI: https://doi.org/10.1007/s10876-020-01929-x

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