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Biological Selenium Nano-particles Modify Immune Responses of Macrophages Exposed to Bladder Tumor Antigens

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Abstract

Biological nanoparticles are considered to improve treatment with the least negative complications. Selenium nanoparticles have been used to treat diseases such as pathogenic infections and cancers. In this study, the effect of selenium nanoparticles on macrophage responses was evaluated. Selenium nanoparticles were synthesized biologically by Lactobacillus Plantarum and confirmed through TEM and SEM microscopy, EDX, and XRD characterizations. Macrophage cells were cultured and treated only with selenium nanoparticles and in combination with the bladder tumor lysate. Moreover, tumor lysate only was used as the other group. The genes expression of IFN-γ, IL-27, IL-12, and MHC-I was assessed by real-time PCR method. The production levels of IFN-γ and IL-27 cytokines were evaluated by ELISA assay. Selenium nanoparticles in combination with the tumor lysate increased the genes expression of IFN-γ, IL-27, IL-12, and MHC-I after 24 h and 48 h of treatment. Also, IFN-γ and IL-27 production was increased in the group treated with selenium nanoparticles in combination with the tumor lysate after 48 h and 72 h of treatment. The highest effect of selenium nanoparticles was observed after 48 and 72 h of treatment in the genes expression and cytokines production, respectively. Therefore, the optimum effect of selenium nanoparticle acts as a treatment dependent-manner.

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Acknowledgements

This work was supported by: National Natural Science Foundation of China, 81502205, China Postdoctoral Science Foundation Grant, 2018M631175. Science Incubation Found of Shaanxi Provincial People’s Hospital, 2015YX-2. National Natural Science Foundation of Shaanxi, 2017JM8093. National Natural Science Foundation of Shaanxi, 2019JM-069. Shaanxi key research and development program, 2017ZDXM-SF-050. The projects 1, 2, 4, and 5 were awarded to Liang Liang. Projects 3 and 6 were awarded to Sun Yi

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Authors and Affiliations

  1. Department of Urology, First Affiliated Hospital of Xi’an Jiaotong University, 277 West Yanta Road, Xi’an, 710061, Shaanxi, China

    Liang Liang

  2. Department of Urology, Shaanxi Provincial People’s Hospital, Xi’an, 710068, Shaanxi, China

    Pan Liang, Deng Qian, Guan Zhenfeng, Cheng Yongyi & Sun Yi

  3. Department of Urology, Affiliated Hospital of Northwestern Polytechnical University, Xi’an, 710068, Shaanxi, China

    Sun Yi

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  1. Pan Liang
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  2. Deng Qian
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  3. Guan Zhenfeng
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  4. Cheng Yongyi
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  6. Liang Liang
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SY and LL designed study. PL and DQ performed the assays. GZ and CY analyzed data. All the authors contributed to write and revise the manuscript.

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Correspondence to Sun Yi or Liang Liang.

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Liang, P., Qian, D., Zhenfeng, G. et al. Biological Selenium Nano-particles Modify Immune Responses of Macrophages Exposed to Bladder Tumor Antigens. J Clust Sci 32, 1623–1633 (2021). https://doi.org/10.1007/s10876-020-01920-6

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